不同剂量托烷司琼对肛肠手术术后恶心、呕吐的预防效果分析

目的探讨不同剂量托烷司琼对肛肠手术术后恶心、呕吐的预防效果。方法选择本院2013年1月至2016年12月收治的97例择期行肛肠手术者,根据随机数字表法,将97例患者分为A组(49例)及B组(48例),两组均采用腰硬联合麻醉,术毕前30min均行自控镇痛,A组于腰麻成功后静脉注射5mg托烷司琼,术毕静脉注射2.5mg托烷司琼,B组于腰麻成功后静脉注射5mg托烷司琼,术毕静脉注射5mg托烷司琼。对比两组术后24h时的镇痛、镇静程度,对比两组术后24h内的恶心、呕吐发生率,对比两组患者术后24h内的恶心、呕吐发生程度及不良反应发生率。结果两组术后24h的VAS评分及镇静评分对比无统计学意义(P>0.05),A组的恶心、呕吐发生率明显低于B组(P<0.05)。A组的恶心、呕吐发生程度较B组严重(P<0.05)。两组患者均完成治疗,治疗过程中均未出现椎体外系反应或镇静过度,两组均未发生明显的头晕、头痛、眩晕、便秘情况。结论肛肠手术术毕给予5mg托烷司琼,可降低患者术后的恶心、呕吐发生率及发生程度,且应用安全。

The preventive effect analysis of tropisetron different doses on nausea and vomiting after anorectal surgery

Objective To investigate the preventive effect of tropisetron different doses on nausea and vomiting after anorectal surgery.Methods 97 cases with elective anorectal surgery admitted to our hospital from January 2013 to December 2016 were selected.97 patients were divided into group A(49 cases) and group B(48 cases) according to the random number table method.Two groups were given combined lumbar and epidural anesthesia,and controlled analgesia was administered 30 min after operation.In the group A,5 mg tropisetron was injected intravenously after lumbar anesthesia,and 2.5 mg tropisetron was injected intravenously after surgery,in the group B,the patients were received 5 mg tropisetron intravenously after lumbar anesthesia and 5 mg tropisetron intravenously after surgery.The analgesia degree and sedation 24 h after the operation was compared in two groups,and the nausea and vomiting incidence within 24 h after the operation were compared in two groups,and the nausea and vomiting incidence and adverse reactions within 24 h after the operation in two groups were compared.ResultsThe VAS scores and sedation scores at 24 h after operation in two groups had no statistical significance(P>0.05),while the nausea and vomiting incidence in group A was significantly lower than that in the group B(P<0.05).The nausea and vomiting incidence in the group A was more serious than that in the group B(P<0.05).Patients in both groups were completed the treatment,and there were no extracorporeal system reaction or excessive sedation during the treatment,and no significant dizziness,headache,dizziness or constipation occurred in either group.Conclusion5 mg tropisetron after anorectal surgery could reduce the postoperative nausea and vomiting incidence in patients,and which was safe to apply.