| UPLC/ESI-Q-TOF MS法分析远志中的化学成分 |
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| 引用本文： | 柴士伟,杨帆,于卉娟,王跃飞. UPLC/ESI-Q-TOF MS法分析远志中的化学成分[J]. 天津中医药大学学报, 2018, 35(1): 60-64 |
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| 作者姓名： | 柴士伟 杨帆 于卉娟 王跃飞 |
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| 作者单位： | 天津中医药大学第一附属医院, 天津 300193,天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 300193;天津国际生物医药联合研究院, 中药新药研发中心, 天津 300457,天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 300193;天津国际生物医药联合研究院, 中药新药研发中心, 天津 300457,天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 300193;天津国际生物医药联合研究院, 中药新药研发中心, 天津 300457 |
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| 基金项目： | 天津中医药大学第一附属医院2016年度新医疗新技术项目（2016012）。 |
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| 摘 要： | [目的]阐明远志中的化学成分。[方法]采用超高效液相色谱-电喷雾离子化-四级杆飞行时间串联质谱（UPLC/ESI-Q-TOF MS）法分析远志中的化学成分，采用Masslynx V 4.1软件，通过分析准分子离子和二级碎片离子信息，并进一步根据标准品的色谱保留时间和质谱裂解规律，鉴定远志中的化学成分。[结果]鉴定了远志中29个化学成分，主要为口山酮、低聚糖酯、皂苷类成分。[结论]总结归纳了远志药材中主要化学成分的质谱裂解规律，阐明了远志中的主要化学成分。
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| 关 键 词： | 超高效液相色谱-电喷雾离子化-四级杆飞行时间串联质谱 远志 化学成分 |
| 收稿时间： | 2017-10-23 |
Analysis of chemical constituents of Radix Polygalae by UPLC/ESI-Q-TOF MS |
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| CHAI Shiwei,YANG Fan,YU Huijuan and WANG Yuefei. Analysis of chemical constituents of Radix Polygalae by UPLC/ESI-Q-TOF MS[J]. Journal of Tianjin University of Traditonal Chinese Medicine, 2018, 35(1): 60-64 |
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| Authors: | CHAI Shiwei YANG Fan YU Huijuan WANG Yuefei |
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| Affiliation: | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Tianjin State Laboratory of Modern Chinese Medicine-Province and Ministry co-established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China,Tianjin State Laboratory of Modern Chinese Medicine-Province and Ministry co-established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China and Tianjin State Laboratory of Modern Chinese Medicine-Province and Ministry co-established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China |
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| Abstract: | [Objective] To elucidate the chemical constituents of Radix Polygalae (RP).[Methods] Ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/ESI-Q-TOF) controlled by Masslynx V 4.1 software was employed for identification of the components in RP. By integrating the information of quasi-molecular and fragment ion, and the retention time and fragment pattern of standards, compounds of RP were identified.[Results] The 29 compounds including xanthones, oligosaccharide esters and saponins of RP were identified.[Conclusion] In this study, the fragment pattern of major compounds in RP was summarized, which provided a basis for further elucidation of chemical substances in RP. |
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| Keywords: | UPLC/ESI-Q-TOF MS Radix Polygalae chemical constituent |
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