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| 胂酸基乙酸与10-羟基喜树碱对肝癌细胞 SMMC-7721生长的协同抑制作用 | |
| 引用本文： | 罗波,郑小莉,王琼,李洪. 胂酸基乙酸与10-羟基喜树碱对肝癌细胞 SMMC-7721生长的协同抑制作用[J]. 泸州医学院学报, 2005, 28(2): 123-125 |
| 作者姓名： | 罗波 郑小莉 王琼 李洪 |
| 作者单位： | 泸州医学院生物化学教研室,四川泸州,646000 |
| 摘 要： | 目的:了解胂酸基乙酸(ASAC)与10-羟基喜树碱(10-HCPT)对肝癌细胞SMMC-7721细胞生长的协同抑制效果.方法:两药组合和单药以不同浓度分别作用于生长良好的SMMC-7721细胞,分别在第24h、48h和72h终止作用,以MTT实验测定每组药物对SMMC-7721细胞的抑制率大小.结果:协同作用组比单药组的抑制效果好.在第48h和72h协同组有显著性差异(P<0.05).结论:ASAC与10-HCPT这两种促癌细胞凋亡的药物对SMMC-7721细胞生长具有周期协同抑制作用. |
| 关 键 词： | 胂酸基乙酸 10-羟基喜树碱 肝癌细胞SMMC-7721 协同抑制 |
| 文章编号： | 1000-2669(2005)2-0123-03 |
| 修稿时间： | 2004-09-24 |
CO-INHIBITION OF ARSACETYL AND 10-HYDROXYLCAMPTOTHECINE ON HEPATOMA CELLS OF SMMC-7721 |
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| Luo Bo,et al. CO-INHIBITION OF ARSACETYL AND 10-HYDROXYLCAMPTOTHECINE ON HEPATOMA CELLS OF SMMC-7721[J]. Journal of Luzhou Medical College, 2005, 28(2): 123-125 | |
| Authors: | Luo Bo et al |
| Affiliation: | Luo Bo,et alDepartment of Biochemistry,Luzhou Medical College |
| Abstract: | Objective: To investigate the co-inhibition effect of arsacetyl (ASAC)and 10-Hydroxylcamptothecine(10-HCPT ) on hepatoma cells of SMMC-7721. Methods: The well-gro wing hepatoma cells of SMMC-7721 were treated by the above two drugs combined or singularly in various concentrations. The inhibition effect of each group on he patoma cells of SMMC-7721 was measured at once by the experiment of MTT after th e treatment was stopped within 24, 48 and 72 hours respectively. Res ults: The groups with the combination of two drugs register more eff ects of co-inhibition than the groups treated by single drug. The co-treated gro ups which were measured at the end of 48 and 72 hours show distinctive differenc e (P<0.05). Conclusion: By inducing apoptosi s, ASAC and 10-HCPT may have periodical co-inhibition on hepatoma cells of SMMC- 7721. |
| Keywords: | Arsacetyl 10-Hydroxylcamptothecine Hepatoma cell of SMMC-7721 Co-inhibition |
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