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| 血管紧张素-(1-7)对心肌细胞L-型钙通道的影响 | |
| 引用本文： | 李晓东,尹德录,叶琳,蒋文平.血管紧张素-(1-7)对心肌细胞L-型钙通道的影响[J].临床心血管病杂志,2003,19(11):674-676. |
| 作者姓名： | 李晓东 尹德录 叶琳 蒋文平 |
| 作者单位： | 1. 山东省立医院保健科,济南,250021 2. 连云港市人民医院心内科 3. 苏州大学附属第一医院心内科 |
| 摘 要： | 目的 :研究血管紧张素 (1 7) Ang (1 7) ]对正常豚鼠心室肌细胞L 型钙离子通道的影响 ,旨在探讨Ang (1 7)发挥降压作用的离子通道及分子基础。 方法 :应用膜片钳全细胞记录技术。结果 :Ang (1 7)可使ICa L呈浓度依赖性增加 ,选择性AngⅠ型 (AT1)受体拮抗剂缬沙坦或非选择性AT1受体拮抗剂Sarthran(Sar)均可消除Ang (1 7)增加ICa L的作用。结论 :Ang (1 7)通过AT1受体增加ICa L,其降压作用不是通过抑制钙离子内流而实现的。 |
| 关 键 词： | 血管紧张素 心肌 钙离子通道 电生理学 |
| 文章编号： | 1001-1439(2003)11-0674-03 |
| 修稿时间： | 2002年12月31 |
Effect of angiotensin-(1-7)on L-type calcium channel in guinea pig myocytes |
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| LI Xiaodong,YIN Delu,YE Lin,JIANG Wenping.Effect of angiotensin-(1-7)on L-type calcium channel in guinea pig myocytes[J].Journal of Clinical Cardiology,2003,19(11):674-676. | |
| Authors: | LI Xiaodong YIN Delu YE Lin JIANG Wenping |
| Institution: | LI Xiaodong 1 YIN Delu 2 YE Lin 1 JIANG Wenping 3 |
| Abstract: | Objective:To investigate the mechanism of hypotensive effects of angiotensin(Ang)-(1-7) in guinea pig.Methods:Membrane currents were recorded with patch electrodes in a whole-cell clamp configuration.Results:The present results showed that: I Ca-L was increased by Ang-(1-7) in a concentration dependent manner. The effects of Ang-(1-7) on I Ca-L can be eliminated by specific AT 1 antagonist Valsartan and non-specific AT antagonist Sarthran.Conclusion:These results suggest that: Ang-(1-7) increase the amplitude of I Ca-L through AT 1 receptor. The hypotensive effects of Ang-(1-7) have no relationship with inward calcium current increase. |
| Keywords: | Angiotensin Myocardium Calcium channels Electrophysiology |
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