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Altered norepinephrine metabolism following long-term weight recovery in patients with anorexia nervosa |
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| Authors: | W H Kaye D C Jimerson C R Lake M H Ebert |
| Affiliation: | 1. Walter H. Kaye, M.D., is in the Laboratory of Psychology and Psychopathology USA;2. David C. Jimerson, M.D., is in the Section on Experimental Therapeutics, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD USA;3. M.D. C. Raymond Lake, M.D., Ph.D., is in the Departments of Psychiatry and Pharmacology, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, MD USA;4. Michael H. Ebert, M.D., is in the Department of Psychiatry, Vanderbilt University, Nashville, TN USA. |
| Abstract: | This study evaluated the relationship between noradrenergic function and long-term weight recovery in patients with anorexia nervosa. Eleven patients with long-term weight maintenance (6 to 72 months) had lower plasma and cerebrospinal fluid concentrations of norepinephrine and 3-methoxy-4-hydroxy-phenylglycol than did healthy controls. Reduced noradrenergic activity may be associated with long-term stability of weight recovery in patients with anorexia nervosa. |
| Keywords: | Anorexia nervosa norepinephrine 3-methoxy-4-hydroxyphenylglycol |
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