Prognostic impact of bone marrow karyotype in childhood acute lymphoblastic leukaemia: Swedish experiences 1986-91 |
| |
| Authors: | E Forestier,G Gustafsson,A von,Heideman ,S Heim,O Hernell,F Mitelman,I Nordenson,B Swolin,S Sö derhä ll |
| |
| Affiliation: | Departments of Paediatrics, University of Umeå, Umeå;Departments of Clinical Genetics, University of Umeå, Umeå;Departments of Paediatrics;Departments of Clinical Genetics, Karolinska Hospital, Stockholm;Department of Clinical Genetics, University Hospital, Uppsala;Department of Clinical Genetics, University Hospital, Lund;Department of Clinical Chemistry, Sahlgrenska University Hospital, Göteborg, Sweden |
| |
| Abstract: | Abstract The prognostic value of cytogenetic classification in acute lymphoblastic leukaemia (ALL) was evaluated in Swedish children below 16 years of age ( n = 372) diagnosed between 1986 and 1991. A bone marrow karyotype was obtained in 281 cases, of which 149 (53%) showed clonal abnormalities. Event-free survival (p-EFS) was 0.64–0.69 in patients with diploid and pseudodiploid karyotype. Patients with massive hyperdiploidy (> 50 chromosomes) had the best outcome (p-EFS = 0.76) and those with hypodiploidy (< 46 chromosomes) had the worst (p-EFS = 0.33). White blood cell count and age were the strongest predictors of outcome. The karyotype reached borderline significance. The diagnostic karyotype was also a predictor of outcome after relapse, with hyperdiploid patients doing better than the others. The presence of a structural chromosomal abnormality did not constitute a negative prognostic factor when intensive chemotherapy was given. |
| |
| Keywords: | Childhood lymphoblastic leukaemia cytogenetics event-free survival |
|
|
