B族维生素及同型半胱氨酸与复发性流产的关系

目的 测定血清叶酸、维生素B12、同型半胱氨酸及红细胞叶酸水平,探讨其与早期原因不明复发性流产的关系.方法 分别采用磁微粒酶免疫分析方法、ELISA方法及电化学发光法测定流产组与对照组外周血中血清叶酸、维生素B12、同型半胱氨酸及红细胞叶酸水平.结果 76例早期原因不明复发性流产患者(流产组)与40例正常同期育龄期妇女(对照组)比较,血清叶酸( t=-3.631,P＜0.005)、维生素B12(t=-4.790,P＜0.005)、同型半胱氨酸(t=3.019,P＜0.005)及红细胞叶酸(t=-3.640,P＜0.005),均有显著性差异.流产组A组(补充0.4mg/d叶酸片)与B组(补充5mg/d叶酸片及复合维生素B),2组补充叶酸后1个月与首诊比较,血清叶酸(t=2.131,P＜0.005)及同型半胱氨酸(t=2.685,P＜0.05),均有显著性差异.结论 体内叶酸水平低下可能是早期原因不明复发性流产发生、发展的一个重要因素,它的检测对于早期原因不明复发性流产患者的预防及治疗具有一定的临床意义.

Correlation between serum FA, VitB12, HCY and red blood cell FA level in patients with early unexplained recurrent pregnancy loss

Objective To determine the serum levels of folio acid, vitamin B12, homocysteine （HCY） and red blood cell folio acid and explore the correlation between them and early unexplained recurrent pregnancy loss （URPL）. Methods The serum levels of serum folio acid, vitamin BI2, HCY and red blood cell folio acid in abortion group and control group were measured by magnetic beads enzyme immunoassay, enzyme linked immunosorbent assay （ELISA） and electrochemiluminescence assay （ECLA） methods, respectively. Results The mean levels of serum folic acid, vitamin B12, HCY and red blood cell folic acid were significantly different between 76 cases of URPL （abortion group） and 40 eases of simultaneous women of childbearing age （control group）（t value was -3. 631, -4. 790, 3. 019 and -3. 640, respectively, all P 〈 O. 005）. Compared with the levels of serum folic acid and HCY at initial diagnosis, they were significantly different one month after supplement both in group A （supplementing folic acid tablets, 0. 4mg/d ） and group B （supplementing folio acid tablets and compound vitamin B, 5 rag/d） in abortion group （t value was 2. 131 and 2. 685, respectively, beth P 〈 0. 05 ）. Cnnelusion Folic acid deficiency in body is likely to be an important factor in occurrence and development of early URPL. The detection of folic acid deficiency is helpful for preventing and treating early URPL in clinics.