湖南省浏阳市11445例妇女HPV感染情况分析

【目的】了解湖南省浏阳市地区人乳头瘤病毒（H PV ）感染的分布特点，为子宫颈癌的防治提供相关依据。【方法】采用导流杂交反斑点印迹（Reverse dot blo ，t RDB）快速基因分型监测技术对2009年6月至2012年6月在湖南省浏阳市人民医院就诊的11445例女性患者进行21种HPV基因亚型的检测。【结果】11445例检测中总的感染率为38．8％，其中高危感染率为35．9％，低危感染率为2．9％，共检测到19种基因型，其中以52型感染率最高，其他常见型分别为：16、58、CP8304、53、68、6、11型，其中45及43型未检测出。 HPV高危感染率各年龄组中≤30岁组和＞50岁组明显高于其他两组（31～50岁年龄段）（ P ＜0．05）。高危 HPV感染者薄层液基细胞学检测（TCT）异常行宫颈活检，其中＞50岁者宫颈癌检出率高于＜50岁者，但＞50岁者宫颈上皮内瘤变（CIN）Ⅰ检出率低于＜50岁者，＞40岁者CIN Ⅱ检出率高于＜40岁者，且＞50岁者CINⅡ检出率高于41～50岁者。多重感染率＞50岁组高于其他三组（＜50岁年龄段）。高危HPV多重感染中年龄＞40岁者CIN Ⅲ检出率高于＜40岁者。【结论】湖南省浏阳市地区 HPV感染的基因分型符合亚洲人群分布规律，但有地区特点。且高危感染者中宫颈活检阳性率有随年龄增长而增高的趋势，＞50岁感染高危H PV者要加强随访，多重感染且＞40岁者要注意加强随访。

Analysis of HPV Infection Among 11,445 Women in Liuyang City of Hunan Province

Objective] To understand the distribution of human papillomavirus （HPV ） infection in Liuyang city of Hunan province so as to provide the relevant evidence for cervical cancer .Methods] Rapid genotyping method with reverse dot blot（RDB） was used to detect 21 HPV sub‐genotypes of 11 ,445 female patients in Liuy‐ang city of Hunan province from June 2009 to June 2012 .Results]Among 11 ,445 patients ,the overall infection rate was 38 .8% ,and the high‐risk infection rate was 35 .9% ,and the low‐risk infection rate was 2 .9% .The 19 genotypes were detected . The infection rate of HPV52 was the highest . The other common genotypes were HPV16 ,58 ,CP8304 ,53 ,68 ,6 and 11 .HPV45 and HPV43 genotypes were not detected .High‐risk infection rate in the age groups with ≤30 years old and 〉50 years old was higher than those in other two groups （between 31 and 51 years old）（ P 〈0 .05） .High‐risk HPV infection patients with abnormal TCT received cervical biopsy . The detection rate of cervical cancer in patients with 〉 50 years old was higher than that in patients with 〈 50 years old ,but the detection rate of intraepithelia neoplasia grade Ⅰ （CINⅠ ） in patients with 〉50 years old was lower than that in patients with 〈50 years old ,and the detection rate of intraepithelia neoplasia grade Ⅱ（CINⅡ） in patients with 〉40 years old was higher than that in patients with 〈40 years old ,and the detection rate of CINII in patients with 〉50 years old was higher than that in patients with 41~50 years old .The multi‐infection rate in age group with 〉50 years old was higher than those in other 3 age groups（〈50 years old ） .The detection rate of intraepithelia neoplasia grade Ⅲ（CINⅢ） in patients with 〉40 years old was higher than that in patients with 〈40 years old .Conclusion]The genotyping of HPV infection in Liuyang city of Hunan province is consistent with the distribution regularity of Asian population ,but has some regional characteristics .The posi