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探讨 Graves 病甲亢患者 TPOAb 和 TGAb 含量与手术治疗后甲减的关系
引用本文:李洲成,伍石华,向元楚,钟荣国,石斌,周铁兴,王鑫. 探讨 Graves 病甲亢患者 TPOAb 和 TGAb 含量与手术治疗后甲减的关系[J]. 湖南医学, 2014, 0(4): 656-658
作者姓名:李洲成  伍石华  向元楚  钟荣国  石斌  周铁兴  王鑫
作者单位:邵阳医学高等专科学校附属医院甲乳外科,湖南邵阳422000
基金项目:湖南省科技厅基金资助(2011SK3032)
摘    要:【目的】测定手术治疗前Graves病甲状腺功能亢进(甲亢)患者血清甲状腺过氧化物酶抗体( T POAb)和甲状腺球蛋白抗体( TGA b)水平,探讨其在手术治疗后与甲状腺功能减退(甲减)发生的关系。【方法】根据手术治疗前TPOA b、TGA b的检测结果,将198例患者分成3组:双阴组12例,单阳组32例,双阳组154例,比较各组间甲减的发生率。再将双阳组的154例患者,按TPOA b、TGA b滴度水平的高低分成3组:A组79例,B组65例,C组10例,进一步探讨手术治疗前TPOA b、TGA b滴度水平的高低与甲减的关系。【结果】手术治疗后甲减发生率差异有统计学意义( P<0.005)。双阳组的154例患者,其TPOAb、TGA b滴度水平高低与甲减发生率相关( P<0.005)。【结论】TGAb、TPOA b滴度水平的检测对于甲亢手术治疗后甲减的预测有指导作用。

关 键 词:甲状腺功能亢进症  抗体  甲状腺功能减退症  格雷夫斯病

Correlation Between Serum Levels of TPOAb and TGAb in Patients with Graves Hyperthyroidism and the Incidence of Hypothyroidism after Subtotal Thyroidectomy
Affiliation:LI Zhou-cheng , XIANG Yuan-chu, ZHONG Rong-guo,et al ( Department of Thyroid and Breast Surgery, Affiliated Hospital of Shaoyang Medical School, Hunan 422000,China )
Abstract:[Objective]To measure serum levels of thyroid peroxidase antibody (TPOAb ) and thyroglobulin antibody (TGAb) in patients with Graves hyperthyroidism before surgery ,and to explore their correlation with the incidence of hy-pothyroidism after surgery .[Methods]According to the results of TPOAb and TGAb ,198 patients were divided into both negative TPOAb and TGAb group( n=12) ,positive TPOAb or TGAb group( n = 32) and both positive TPOAb and TGAb( n=154) .According to the titer levels of TPOAb and TGAb ,154 patients with both positive TPOAb and TGAb were also divided into group A ( n=79) ,group B( n=65) and group C( n=10) .The correlation of the titer levels of TPOAb and TGAb with hypothyroidism before the operation was further discussed .[Results] There was significant difference in the incidence of hypothyroidism after the operation among three groups ( P〈0 .005) .Among 154 patients of both positive TPOAb and TGAb group ,the titer levels of TPOAb and TGAb were related with the incidence of hyperthy-roidism( P〈0 .005) .[Conclusion] The detection of serum levels of TPOAb and TGAb is of significance for predicting the incidence of hypothyroidism after surgery .
Keywords:Hyperthyroidism  Antibodies  Hypothyroidism  Graves Disease
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