| 基质金属蛋白酶-2、基质金属蛋白酶-9与特发性肺纤维化的研究进展 |
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| 引用本文： | 王妍妮,王昌明. 基质金属蛋白酶-2、基质金属蛋白酶-9与特发性肺纤维化的研究进展[J]. 国际呼吸杂志, 2014, 34(18): 1421-1424 |
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| 作者姓名： | 王妍妮 王昌明 |
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| 作者单位： | 541001,桂林医学院附属医院呼吸内科 |
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| 摘 要： | 基质金属蛋白酶是一组金属依赖的可降解细胞外基质的蛋白酶类.基质金属蛋白酶与基质金属蛋白酶组织抑制因子之间的比例失衡可能导致细胞外基质的降解异常,这可以促进纤维化的过程.近年来随着研究的进展,发现基质金属蛋白酶-2和基质金属蛋白酶-9与特发性肺纤维化有着密切的关系,现就此作一综述.
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| 关 键 词： | 基质金属蛋白-2 基质金属蛋白-9 细胞外基质 特发性肺纤维化 |
Research advances of matrix metalloproteinase-2 and matrix metalloproteinase-9 in idiopathic pulmonary fibrosis |
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| Wang Yanni,Wang Changming. Research advances of matrix metalloproteinase-2 and matrix metalloproteinase-9 in idiopathic pulmonary fibrosis[J]. International Journal of Respiration, 2014, 34(18): 1421-1424 |
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| Authors: | Wang Yanni Wang Changming |
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| Affiliation: | (Department of Respiratory Medicine ,Affiliated Hospital of Guilin Medical College, Guilin 541001 , China) |
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| Abstract: | Matrix metalloproteinase （MMPs） is a kind of protease with metals dependence which can degrade extracellular matrix.Imbalance in MMPs and tissue inhibitor of matrix metalloproteinase may lead to abnormal degration of extracellular matrix.Previous research has indicated that MMP-2 and MMP 9 have a close relationship with idopathic pulmonary fibrosis.This article reviews the relationship of MMP 2.MMP-9 with idopathic pulmonary fibrosis. |
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| Keywords: | Matrix metalloproteinase-2 Matrix metalloproteinase-9 Extracellular matrix Idopathic pulmonary fibrosis |
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