维生素D调节支气管哮喘气道平滑肌的研究进展

气道平滑肌的过度增生、肥大及功能异常，可能是支气管哮喘（简称哮喘）的发病机制之一。新近研究发现，除了对骨骼和钙代谢有明确的作用，维生素D还可调节气道平滑肌的增殖、收缩，并在哮喘的免疫调节方面起着重要的调控作用，从而影响气道炎症、气道重塑等哮喘的病理生理过程。本文就维生素D调节哮喘气道平滑肌的研究进展作一综述。

The effects of Vitamin D on airway smooth muscle in bronchial asthma

Excessive hyperplasia, hypertrophy and dysfunction of airway smooth muscle may be one of the pathogenesis of bronchial asthma （asthma）. In addition to the distinct role of Vitamin D in bone and calcium metabolism, Vitamin D may regulate the proliferation and contraction of airway smooth muscle. Besides, Vitamin D plays a pivotal role in immunoregulation of asthma. Those may influence the pathophysiological process of asthma,including airway inflammation, airway remodeling and so on. This review summarizes the effects of Vitamin D on airway smooth muscle in asthma.