艾司西酞普兰与西酞普兰对利血平致抑郁障碍的疗效与安全性评价

目的探讨艾司西酞普兰与西酞普兰对利血平致抑郁障碍的疗效及安全性。方法选取2011年6月－2013年7月收治的利血平所致抑郁障碍60例患者作为研究对象,随机分为研究组和对照组,每组30例。研究组采用艾司西酞普兰系统治疗,每天10 mg口服;对照组采用西酞普兰系统治疗,每天20 mg口服。分别于治疗前、治疗第1、2、4、6周末进行汉密尔顿抑郁量表（HAMD）和不良反应量表（TESS）评定两组患者临床治疗情况。结果两组于治疗第2周末,HAMD评分均较治疗前有显著性下降（P〈0.05）;其中研究组在治疗第1、2周末HAMD评分下降均较对照组更为显著（P〈0.05）。而在治疗第4、6周末时两组间的HAMD评分及总有效率比较,差异无统计学意义（P〉0.05）。两组治疗后不良反应均较轻微,且多出现在用药初期,随着时间的延长可减轻或消失。两组不良反应发生率差异无统计学意义（P〉0.05）。结论艾司西酞普兰与西酞普兰均可有效改善利血平引起的抑郁症状,而艾司西酞普兰起效更快,治疗初期效果更显著,治疗依从性更高。

Curative effect and safety evaluation of Escitalopram and citalopram on reserpine to depressive disorders

Objective To explore curative effect and safety evaluation of Escitalopram and citalopram on reserpine to depressive disorders. Methods 60 cases of patients with depressive disorders because of reserpine were randomly divided into research group and control group, 30 cases of each group.Patients in the research group were treated with escitalopram, daily 10 mg oral, and the Control group were with citalopram, 20 mg oral daily. All patients in two groups were going to be evaluated with HAMD and TESS scale at the time before treatment and the weekend of 1st, 2nd, 4th, 6th after treatment. Results HAMD scores were decreased at 2nd weekend, and HAMD scores were significantly less than that before treatment（P〈0.05）. HAMD scores of research group were both less than those of the control group significantly at 1st and 2nd weekend（P〈0.05）. And HAMD scores and total effective rate of the two groups had no significant difference from each other at 4th, 6th weekend（P〈0.05）. Adverse reactions were gental and always in the early days, and they would reduce or disappear. Adverse reactions of the two groups had no significant difference from each other（P〈0.05）. Conclusion Escitalopram and citalopram all can effectively improve depressive symptoms caused by reserpine, and escitalopram works faster and more effectly in the early treatment.