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Diffusion tensor imaging of white matter injury in a rat model of infantile hydrocephalus
Authors:Weihong Yuan  James P. McAllister II  Diana M. Lindquist  Nicholas Gill  Scott K. Holland  David Henkel  Akila Rajagopal  Francesco T. Mangano
Affiliation:(1) Department of Radiology, Pediatric Neuroimaging Research Consortium, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA;(2) Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA;(3) Department of Neurosurgery, Division of Pediatric Neurosurgery, Primary Children’s Medical Center, Salt Lake City, UT, USA;(4) The University of Utah, Salt Lake City, UT, USA;(5) Department of Radiology, Imaging Research Center, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA;(6) University of Cincinnati College of Medicine, Cincinnati, OH, USA;(7) Department of Neurological Surgery, Division of Pediatric Neurosurgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA;(8) Division of Pediatric Neurosurgery, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, MLC 2016, 3333 Burnet Avenue, Cincinnati, OH 44529, USA;
Abstract:

Objective  

Diffusion tensor imaging (DTI) is a non-invasive MRI technique that has been used to quantify white matter (WM) abnormality in both clinical and experimental hydrocephalus (HCP). However, no DTI study has been conducted to characterize anisotropic diffusion properties in an animal model of infantile HCP. This DTI study was designed to investigate a rat model of HCP induced at postnatal day 21, a time developmentally equivalent to the human infancy.
Keywords:
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