| 鱼油中EPA和DHA对麻醉大鼠左室功能的影响 |
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| 引用本文： | 周建政,吴葆杰.鱼油中EPA和DHA对麻醉大鼠左室功能的影响[J].中国海洋药物,1995,14(3):5-8. |
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| 作者姓名： | 周建政 吴葆杰 |
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| 作者单位： | 山东医科大学基础部药理学教研室，山东医科大学基础部药理学教研室，山东医科大学基础部药理学教研室 济南 250012 军事医学科学院毒物药物研究所 北京，100850，济南 250012，济南 250012 |
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| 摘 要： | 观察了鱼油对麻醉大鼠基础左室功能和异丙肾上腺素（ＩＳＯ）诱导的左室功能改变的影响，实验结果表明，鱼油（ＥＰＡ和ＤＨＡ，７０％，１．４ｍＬ／ｋｇ）摄入２ｗ对大鼠基础心功能无显著影响，但可显著地抑制ＩＳＯ（１０＾－６ｍｏｌ／Ｌ，１０＾－５ｍｏｌ／Ｌ，１０＾－４ｍｏｌ／Ｌ）诱导的正性肌力和正性频率作用，对ＩＳＯ诱导的心室前负荷的改变地无显著影响，结果提示，ＥＰＡ和ＤＨＡ的摄和诃能影响大鼠心肌细胞膜上β－
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| 关 键 词： | 鱼油 左室功能 二十碳五烯酸 麻醉 DHA |
EFFECT OF FISH OIL ON LEFT VENTRICULAR FUNCTION IN ANESTHETIZED RATS |
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| Zhou Jianzheng,Wu Baojie,Zhang Xiumei.EFFECT OF FISH OIL ON LEFT VENTRICULAR FUNCTION IN ANESTHETIZED RATS[J].Chinese Journal of Marine Drugs,1995,14(3):5-8. |
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| Authors: | Zhou Jianzheng Wu Baojie Zhang Xiumei |
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| Abstract: | The effect of fish oil on the basal left ventricular function and changes of left ventricular function induced by isoprenaline (ISO) was demonstrated in the study. The determination of cardiac performance in vivo showed that supplementation with fish oil (EPA and DMA,70%, 1. 4 mL/kg) had no significant effect on basal cardiac performance,while it could significantly inhibit the gains of +dp/dtmax,Vpm and HR induced by ISCK10 6 mol/L, 10 3 mol/L, 10 4 mol/L) introvenously. The result suggest that supplementation with fish oil have some effects on the function of B-adrenoceptors on rat myocardial membrane. |
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