| 消化性溃疡的治疗靶点 |
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| 引用本文： | 王晨泉,马晓慧,李运曼. 消化性溃疡的治疗靶点[J]. 医学综述, 2012, 18(10): 1520-1524 |
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| 作者姓名： | 王晨泉 马晓慧 李运曼 |
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| 作者单位： | 中国药科大学生理教研室;天津天士力集团研究院药理与毒理研究所 |
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| 摘 要： | 消化性溃疡通常发生在胃和十二指肠球部。消化性溃疡的发生是因胃黏膜的侵袭因素(胃酸、胃蛋白酶、幽门螺杆菌感染、非甾体类抗炎药等)与防御因素(黏液、黏膜屏障、黏膜血流量、前列腺素和表皮生长因子等)间的失衡而引起的。通过对消化性溃疡的治疗靶点进行分析总结,有助于指导其治疗用药及防止复发,同时也有利于研发新的治疗溃疡药物。
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| 关 键 词： | 消化性溃疡 治疗 靶点 |
Therapeutic Targets of Peptic Ulcer |
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| WANG Chen-quan,MA Xiao-hui,LI Yun-man. Therapeutic Targets of Peptic Ulcer[J]. Medical Recapitulate, 2012, 18(10): 1520-1524 |
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| Authors: | WANG Chen-quan MA Xiao-hui LI Yun-man |
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| Affiliation: | 1.(1.Department of Physiology,China Pharmaceutical University,Nanjing 210009,China;2.Department of Pharmacology and Toxicology,Tianjin Tasly Institute,Tianjin 300410,China) |
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| Abstract: | Peptic ulcer usually occurs in the stomach and proximal duodenum when a disturbance in the balance between the defensive(mucus,mucosal barrier,mucosal blood flow,prostaglandin,and epidermal growth factor,etc.)and aggressive factors(gastric acid,pepsin,Helicobacter pylori infection,non-steroidal anti-inflammatory drugs,etc.)on the gastric and duodenal bulb mucosae happens.It can help to choose a suitable treatment and prevention from recurrence and also contributes to the design of new therapeutic drugs for ulcers through the summary of the mechanism and therapeutic targets of peptic ulcer. |
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| Keywords: | Peptic ulcer Therapy Target |
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