| 加味左金丸对胃癌前病变大鼠胃黏膜组织细胞增殖与凋亡的影响 |
| |
| 引用本文： | 孙丽群,唐昃,段秀泉.加味左金丸对胃癌前病变大鼠胃黏膜组织细胞增殖与凋亡的影响[J].中国中西医结合消化杂志,2006,14(4):233-236. |
| |
| 作者姓名： | 孙丽群 唐昃 段秀泉 |
| |
| 作者单位： | 黄石市第一医院,肿瘤内Ⅱ科,湖北,黄石,435001 |
| |
| 摘 要： | 目的]探讨加味左金丸对胃癌前病变大鼠胃黏膜组织细胞增殖与凋亡的影响。方法]将以饮用甲硝基亚硝基胍为主24周制成的胃癌前病变模型大鼠随机分为模型组，维甲酸组，加味左金丸高、中、低剂量组，治疗16周，采用免疫组化SP法，TUNEL法检测胃黏膜组织细胞增殖细胞核抗原（PCNA）、Bcl-2蛋白及凋亡指数（AD）的表达情况。结果]加味左金丸能明显下调胃癌前病变组织细胞的PCNA、Bcl-2的表达，上调AI。结论]抑制细胞增殖，诱导细胞凋亡可能是该方的作用机制之一。
|
| 关 键 词： | 左金丸 加味 胃癌前病变 增殖 凋亡 |
| 文章编号： | 1671-038X（2006）04-0233-04 |
| 收稿时间： | 2005-11-01 |
| 修稿时间： | 2005-11-01 |
Effect of supplemented Zuojin pill on proliferation and apoptosis of gastric mucosa cells in precancerous rats |
| |
| SUN Li-qun,TANG Ze,DUAN Xiu-quan.Effect of supplemented Zuojin pill on proliferation and apoptosis of gastric mucosa cells in precancerous rats[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2006,14(4):233-236. |
| |
| Authors: | SUN Li-qun TANG Ze DUAN Xiu-quan |
| |
| Abstract: | Objective] To study the effect of supplemented Zuojin decoction(SZD) on the proliferation and apoptosis of gastric mucosa cells in the precancerous rat.Methods] All rats were divided into model group,tretinoin group,high-dosage SZD group,middle-dosage SZD group and low-dosage SZD group after lavaged with N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) and so on for 24weeks to make model.The expression of PCNA and Bcl-2 protein and apoptosis index(AI) was detected by immunohistochemistry and TUNEL after treated for 16 weeks respectively.Results] SZD can down-regulated the expression of PCNA and Bcl-2 protein and up-regulated AI.Conclusion] inhabiting cell proliferation and inducing cell apoptosis may be one of mechanisms of SZD treating gastric precancerous lesion. |
| |
| Keywords: | supplemented Zuojin decoction gastric precancerous lesion proliferation apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
