含利福霉素钠注射液方案治疗肺结核的有效性和安全性评价

目的 :评价含利福霉素钠注射液 (SV)方案治疗肺结核的疗效和安全性。方法 :按随机配对法将44例肺结核患者分为利福霉素钠组 2 1例和常规治疗组 2 3例。化疗方案 :治疗组 2 1例采用 2HZE +SV 7HR方案治疗 ,对照组采用 2HRZE 7HR方案治疗。结果 :疗程结束时 ,治疗组痰菌转阴率 85 .7% ,病灶吸收好转率 90 .5 % ,对照组痰菌阴转率60 .9% ,病灶吸收好转率 60 .9% ,两组比较有统计学意义 (P <0 .0 5 )。结论 :含利福霉素钠注射液方案治疗肺结核有助于痰菌转阴和病灶吸收 ,疗效满意

Evaluation of efficacy and safety of rifamycin sodium injection in treatment of patients with pulmonary tuberculosis

AIM: To evaluate the therapeutic effect and safety of the rifamycin sodium injection (SV) in treatment of patients with pulmonary tuberculosis. METHODS: 44 cases of pulmonary tuberculosis were randomly allocated to two groups: rifamycin sodium group and routine treatment group. Chemotherapy regimens: in the rifamycin sodium group, 21 cases were treated with the regimen of 2HZE+SV/7HR; and in the routine treatment group, 23 cases were treated with the regimen of 2HRZE/7HR. RESULTS: The sputum negative conversion rate of the rifamycin sodium group was 85.7 %, and the foci vanishing rate was 90.5 %, while the both rates in the routine treatment group were 60.9 % and 60.9 %, respectively. There was significant difference between the two groups (P< 0.05 ). CONCLUSION: The therapeutic regimen with SV is effective in the sputum negative conversion and vanishing of foci.