Bacterial degradation of microcystin toxins in drinking water eliminates their toxicity. |
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| Authors: | Lionel Ho Anne-Laure Gaudieux Stella Fanok Gayle Newcombe Andrew R Humpage |
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| Affiliation: | Cooperative Research Centre for Water Quality and Treatment, South Australian Water Corporation, PMB 3, Salisbury, SA 5108, Australia. lionel.ho@sawater.com.au |
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| Abstract: | Microcystin-LR and -LA were readily biodegraded by a bacterium, Sphingpoyxis sp. LH21, in a treated reservoir water. Detection of the microcystins was conducted using high-performance liquid chromatography (HPLC), protein phosphatase 2A (PP2A) inhibition assay and a cell-based cytotoxicity assay. The HPLC results correlated well with the two assays. The decrease in cytotoxicity, coupled with the associated decrease in microcystin concentrations, indicated that no cytotoxic by-products were being generated, highlighting the applicability of biodegradation as a feasible treatment option for effective microcystin removal. |
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| Keywords: | Biodegradation Cytotoxicity Microcystin MTT Protein phosphatase 2A (PP2A) Sphingopyxis VERO |
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