New poliovirus vaccines: a molecular approach |
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| Authors: | J.W. Almond G. Stanway A.J. Cann G.D. Westrop D.M.A. Evans M. Ferguson P.D. Minor M. Spitz G.C. Schild |
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| Affiliation: | 1. Department of Microbiology, Medical Sciences, University of Leicester, Leicester LE1 7RH, UK;2. National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RH, UK |
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| Abstract: | ![]()
This article summarizes recent work on the determinants of antigenicity in poliovirus type 3 and reports on experiments in progress aimed at understanding the molecular basis of attenuation in Sabin's type 3 vaccines. Ways in which this new information might be used to produce alternative, safe, inexpensive, multivalent vaccines against polio and other enteroviruses are discussed. |
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| Keywords: | Virus poliomyelitis synthetic antigen molecular genetics poliovirus virulence antigenic sites monoclonal antibodies |
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