| 骨髓来源半成熟树突状细胞诱导大鼠小肠移植免疫耐受 |
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| 引用本文： | 孟松,杨晓俊,朱春富,姜红,吴文溪.骨髓来源半成熟树突状细胞诱导大鼠小肠移植免疫耐受[J].中华实验外科杂志,2010,27(1):760-762,后插2. |
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| 作者姓名： | 孟松 杨晓俊 朱春富 姜红 吴文溪 |
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| 作者单位： | 南京医科大学第一附属医院普外科,210029;常州市第二人民医院普外科; |
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| 摘 要： | Objective To study MyD88 silent semi-mature DC (simDC) inducing immune tolerance in rat small bowel transplantation model. Methods All rats were randomly divided into three groups (n=6). Seven days before transplantation of intestine from F344 donors, Wistar recipient rats were injected with simDC (group A) , imDC (group B) and saline ( group C) through the penile dorsal vein respectively.Small bowel transplantation was performed and the survival time of recipients was observed. Serum IL-2 and IFN-γ levels were assayed. Results The survival time of recipients in group A was ( 13.7±1.2) days, which was significantly longer than that in groups B (8.0±1.0) days,P<0. 05] and C (6. 0±0. 8) days P<0. 05]. The serum levels of IL-2 and IFN-γ in group A were lower than in groups B and C (P<0. 05). Conclusion Depending on the unique phenotypic and functional features of sem-DC,they can induce the transplantation tolerance and prolong the survival of intestinal allografts after transplantatin.
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| 关 键 词： | 树突状细胞 免疫耐受 小肠移植 |
MyD88 silent semi-mature DC induced immune tolerance in rat small bowel transplantation model |
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| MENG Song,YANG Xiao-jun,ZHU Chun-fu,JIANG Hong,WU Wen-xi.MyD88 silent semi-mature DC induced immune tolerance in rat small bowel transplantation model[J].Chinese Journal of Experimental Surgery,2010,27(1):760-762,后插2. |
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| Authors: | MENG Song YANG Xiao-jun ZHU Chun-fu JIANG Hong WU Wen-xi |
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| Abstract: | |
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| Keywords: | MyD88Dendritic cellImmune toleranceMyD88Intestinal transplantation |
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