HR标准化肝脏表观弥散系数值评价肝纤维化程度及其与血清学指标的相关性研究

目的探讨标准化肝脏ADC值定量分析肝纤维化的能力，同时分析其与血清肝纤维化指标的相关性。方法利用MRDwI检查回顾性分析54例肝纤维化患者资料，检测肝纤维化血清学指标HA、LN、PC11I和IV-C，测量不同肝纤维化分期下肝脏ADc值、脾脏ADC值，并计算标；住化肝脏ADC值。分析肝纤维化分期与标准化肝脏ADC值之间的相关性，比较肝纤维化各期标准化肝脏ADc值间的差异，并对血清学指标和标准化肝脏ADC值作相关性分析。结朵血清学指标№、LN、PCIII和IV—c随肝纤维化分期进展依次升高，标准化肝脏ADc值（b=700S／mill。）依次降低，差异具有统计学意义（P〈0．01）；血清生化指标与标准化肝脏ADC值相关性分析，标准化肝脏ADC值与LN、PCIII、HA，IV-C呈负相关。结论MRDwI是有效检测和定量肝纤维化严重程度的影像学方法。血清肝纤维化指标、标准化肝脏ADC值在肝纤维化的诊断中均具有一定价值，两种方法各指标之间存在一定程度的相关性。

Study on Degree of Liver Fibrosis with Apparent Diffusion Coefficient Value of MR Standardized Liver and Its Corre- lation with Serum Markers

Objective To study capacity for quantitative analysis of liver fibrosis with ADC value of standardized liver and analyze its correlation with serum mtu＇kers of liver fibrosis. Methods Imaging data of MR DWl of 54 patients with liver fibrosis was retrospectively analyzed, ;md serum HA,LN,PC III and 1V -C were determined respectively, and the ADC value of liver and spleen measured under different stages of liver fibrosis and ADC value of standardized liver was calculated. Correlation of staging of liver fibrosis with ADC value of standardized liver was analyzed, and difference of ADC value among every staging of liver fibrosis compared, and correlation of serum markers of liver fibrosis and ADC value of standardized liver analyzed. Results Sert.m HA, LN, PC 111 and IV-C rise with staging progress of live fibrosis and the ADC value of standardized liver （b=700s/mm2） decrease successively, and its differences has statistics signifi- cance （P〈0.01）; Among group comparison SO stage could be distinguished from S l, $2. $3 and $4 stage and the S1 stage fromS2. $3 and $4 stage with ADC value of standardized liver, and $2 and $3, $2 and $4, $3 andS4 could not be discriminated. The correlation for serum HA, LN, PC III and IV-C with ADC value of standard- ized liver is negative. Conclusions MR DWI is an effective imaging method for detection and quantification of serious degree of liver fibrosis. Serum markers of liver fibrosis and ADC value of standardized liver are attractive in diagnosis of liver fibrosis, and there is a degree of correlation among the various indicators of both methods.