胰头部肿块型胰腺炎与胰腺癌的关系

胰头部肿块型慢性胰腺炎与胰头癌难以鉴别，虽然其属于良性病变，但有一定的恶变率。慢性胰腺炎基础上的组织增生、萎缩以及癌变过程中，癌基因激活和抑癌基因失活可以导致胰腺癌的发生。影像医学的发展为两者的鉴别诊断提供了直观的影像学证据，但是，目前的诊断方法包括CT、MRI、ERCP、EUS（FNA）和PET-CT都存有一定的不足，导致诊断困难。因此，手术是最终诊断胰腺癌和肿块型慢性胰腺炎的惟一手段。

Relationships between chronic pancreatitis with mass in the head and pancreatic carcinoma

Relationships between chronic pancreatitis with mass in the head and pancreatic carcinoma ZHANG Bo ,NI Quan-xing. Pancreatic Disease Institution, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China Corresponding author: NI Quan-xing, E-mail：tomchang 202@yahoo.com.cn Abstract It is difficult to identify chronic pancreatitis with mass in the head with pancreatic carcinoma. It has the potential for malignant change. In the progress of hyperblastosis and atrophy based on chronic pancreatitis, cancer gene stimulated and anti-cancer gene inactivation may be the causes of canceration. In spite of more clinical examinations including CT、MRI、ERCP、EUS（FNA） and PET-CT can help to make differential diagnosis between the both, it is still difficult in making diagnosis because of their disadvantages. So the surgery is the only method of making final diagnosis of pancreatic cancer or chronic pancreatitis with mass in the head.