Subchronic Toxicity of Inhaled Technical Grade 1,3-Dichloropropene in Rats and Mice

Subchronic Toxicity of Inhaled Technical Grade 1,3-Dichloropropenein Rats and Mice. Stott, W. T., Young, J. T., Calhoun, L. L.,and Battjes, J. E., (1988). Fundam. Appl. Toxicol. 11,207–220.In order to provide a comprehensive subchronic inhalation toxicitystudy of the soil fumigant, technical grade 1,3-dichloropropene(DCPT), male and female Fischer 344 rats and B6C3F1 mice wereexposed to 0, 10, 30,90, or 150 ppm DCPT vapors 6 hr/day, 5days/ week for 13 weeks. The primary target tissues of inhaledDCPT were identified as the nasal mucosa of both sexes of ratsand mice, and the urinary bladder of female mice. In addition,depressed growth rates of all animals exposed to 90 or 150 ppmDCPT (up to 20% in rats and 12% in mice) resulted in a varietyof alterations in hematologjc and clinical chemistry parameters,and changes in organ weights relative to controls. Nasal mucosaleffects consisted of a dose-related slight degenerative effectof nasal olfactory epithelium or a mild hyperplasia of the respiratoryepithelium or both in all animals exposed to 90 or 150 ppm and2 of 10 male rats exposed to 30 ppm DCPT. Some focal areas ofrespiratory metaplasia were also noted in high exposure groupmice. Urinary bladder effects consisted of a diffuse, moderatehyperplasia of the transitional epithelium in female mice exposedto 90 or 150 ppm DCPT. No treatment-related effects were observedin rats or mice exposed to 10 ppm DCPT vapors.