骨碎补外用对实验性豚鼠白癜风的影响*

[目的]探讨骨碎补外用对实验性白癜风豚鼠模型的治疗作用,为中国药典增补其"外用消风祛斑"的功能提供药效学参考依据。[方法]采用过氧化氢化学脱色法制备实验性白癜风豚鼠模型,观察受试药物对豚鼠皮肤黑色素形成及血液中酪氨酸酶(TYR)、胆碱酯酶(CHE)和单胺氧化酶(MAO)的影响。[结果]骨碎补外用能够使实验性白癜风模型有良好的治疗作用,与模型组相比,皮肤黑色素分布含量增加,血液中TYR活力增加、CHE活力增加、MAO活力降低。[结论]骨碎补外用对白癜风豚鼠模型有治疗作用。

Influence of external use of rhizoma drynariae on experimental vitiligo

[Objective] To study the therapeutic effect of external use of rhizoma drynariae on experimental vitiligo guinea pig model, and provide some pharmacodynamics references basis for its function of resolving wind and expelling macula in Chinese Pharmacopeia (ChP).[Methods] Vitiligo was produced by chemical decoloration method. The influence of the tested drug on the guinea pig skin melanin distribution and the blood tyrosinase (TYR), cholinesterase (CHE) and single amine (MAO) were measured.[Results] The external use of rhizoma drynariae showed good effects on the animal models. It could highly improve the skin melanin generation compared with that in model group, and can also increase the activity of TYR, CHE and MAO.[Conclusion] The external use of rhizoma drynariae shows good effects on the guinea pig model model.