芍药苷对强迫游泳小鼠脑内单胺递质的影响*

目的]观察芍药苷的抗抑郁作用及可能的作用机制。方法]利用小鼠强迫游泳实验,观察芍药苷对小鼠不动时间的影响。采用高效液相色谱法(HPLC)法检测小鼠脑组织中单胺神经递质含量变化。结果]芍药苷(100、200 mg/kg组)可显著缩短小鼠强迫游泳的不动时间,并且芍药苷(200 mg/kg组)可升高脑组织中去甲肾上腺素(NE)、多巴胺(DA)和5-羟色胺(5-HT)含量。结论]芍药苷具有一定的抗抑郁作用,其机制可能与增加脑内单胺递质含量有关。

Effect of paeoniflorin on cerebral neurotrnsmitter in forced-swimming mice

Objective] To investigate the antidepressant effects and the possible mechanism of paeoniflorin.Methods] The antidepressant effects was evaluated by forced-swimming tests (FST). The content of monoamine neurotransmitters was measured by the HPLC assay.Results] Paeoniflorin (100 and 200 mg/kg) could significantly reduce the duration of immobility in FST, and Paeoniflorin (200 mg/kg) can significantly increase the contents of Norepinephrine (NE), dopaimine (DA) and 5-hydroxytryptamine (5-HT) in mouse brain.Conclusion] Paeoniflorin has remarkable antidepressant effect, and its mechanism may be involved in monoaminergic nervous system.