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肠道白色念珠菌易位体内机制的研究
引用本文:白晓东,刘贤华,仝青英,张韶峰. 肠道白色念珠菌易位体内机制的研究[J]. 中华医院感染学杂志, 2004, 14(9): 975-978
作者姓名:白晓东  刘贤华  仝青英  张韶峰
作者单位:武警总医院烧伤科,北京,100039
摘    要:目的观察白色念珠菌发生易位的机制. 方法无特殊病原菌(SPF)小鼠分为正常对照组、正常给菌组,给菌后烧伤组、烧伤对照组,观察白色念珠菌黏附计数、易位,肠黏液中特异抗白色念珠菌sIgA;体外观察白色念珠菌黏附、侵入肠上皮细胞内情况. 结果在肠内特异sIgA较低时,白色念珠菌黏附数较多,发生易位;体外实验环境中白色念珠菌浓度越高,黏附、侵入的阳性细胞数量越多. 结论白色念珠菌黏附后侵入肠上皮细胞内,是发生易位的重要途径之一,特异抗白色念珠菌sIgA对此有预防作用.

关 键 词:白色念珠菌  黏附  易位
文章编号:1005-4529(2004)09-0975-04
修稿时间:2003-09-10

Translocation of Intestinal Candida albicans and Its Mechanism
BAI Xiao-dong,LIU Xian-hua,TONG Qing-ying,ZHANG Shao-feng. Translocation of Intestinal Candida albicans and Its Mechanism[J]. Chinese Journal of Nosocomiology, 2004, 14(9): 975-978
Authors:BAI Xiao-dong  LIU Xian-hua  TONG Qing-ying  ZHANG Shao-feng
Abstract:OBJECTIVE To observe the route of Candida albicans translocation. METHODS In vivo, SPF mice were divided into normal control group, gavage group, gavage and burn group, and burn control group. The candida translocation, candida adherence to the intestinal membrane and specific sIgA to candida were investigated. In vitro, the candida adherence to the cultured intestinal epithelial cells was observed. RESULTS The level of specific sIgA to candida in mucus was lower, meanwhile the number of C. albicans adherence to mucosal membrane was higher, and the candida translocation was found. In vitro, the more the environment candida density was, the more the candida adherence and invasion into the intestinal epithelial cells could be found. CONCLUSIONS Invasion after adherence is one of the important route of candida translocation, specific sIgA could prevent it.
Keywords:Candida albicans  Bacterial translocation  Adherence
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