| 非低氧刺激对HIF-1的调控作用 |
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| 引用本文： | 吴恩惠,朱玲玲,范明. 非低氧刺激对HIF-1的调控作用[J]. 军事医学科学院院刊, 2007, 31(3): 275-278 |
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| 作者姓名： | 吴恩惠 朱玲玲 范明 |
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| 作者单位： | 军事医学科学院基础医学研究所,北京,100850 |
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| 摘 要： | 低氧诱导因子1(HIF-1)是组织细胞在低氧状态下诱导产生的主要调节分子,对维持细胞的氧平衡及在低氧状态下细胞的存活和代谢都具有重要作用.最近研究发现,许多非低氧形式的刺激也可影响HIF-1的表达和活性.本文就体外物理因素(如高温、高氧、低温、辐射)和细胞因子等对HIF-1的调控进行综述,并对其可能的作用机制进行了探讨.
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| 关 键 词： | 低氧诱导因子HIF-1 非低氧刺激 高温,诱发 低温 高氧 辐射 低氧诱导因子 刺激 调控作用 stimuli 机制 细胞因子 辐射 低温 高氧 高温 物理因素 活性 表达 影响 发现 研究 氧平衡 分子 调节 氧状态 |
| 文章编号： | 1000-5501（2007）03-0275-04 |
| 修稿时间： | 2006-08-08 |
Regulating effect of non-hypoxic stimuli on HIF-1 |
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| WU En-Hui,ZHU Ling-Ling,FAN Ming. Regulating effect of non-hypoxic stimuli on HIF-1[J]. Bulletin of the Academy of Military Medical Sciences, 2007, 31(3): 275-278 |
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| Authors: | WU En-Hui ZHU Ling-Ling FAN Ming |
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| Affiliation: | Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract: | Hypoxia-induced factor(HIF-1) is the key regulator produced by tissues and cells in hypoxia environment,and plays an important role in maintaining oxygen homeostasis,cell survival and energy metabolism.It is known that HIF-1 is induced by hypoxic stimuli,but recently increasing studies reported that various non-hypoxia stimuli can also regulate the activity and expression of HIF-1.This review focuses on the regulating effects of physical factors(eg.heat,cold,hyperoxia,radiation) and cytokines on activity of HIF-1,and its mechanism. |
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| Keywords: | hypoxia induced factor 1(HIF-1) non-hypoxic stimuli hyperthermia induced hypothermia hyperoxia radiation |
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