Short communication: Trypanosoma cruzi lineage I in endomyocardial biopsy from a north-eastern Brazilian patient at end-stage chronic Chagasic cardiomyopathy |
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| Authors: | Teixeira Marta M G da Silva Flávia Maia Marcili Arlei Umezawa Eufrosina S Shikanai-Yasuda Maria A Cunha-Neto Edécio Kalil Jorge Stolf Noedir Stolf Anna Maria S |
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| Affiliation: | 1. Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de S?o Paulo, S?o Paulo, SP, Brazil;2. Instituto de Medicina Tropical de S?o Paulo, Universidade de S?o Paulo, S?o Paulo, SP, Brazil;3. Laboratório de Imunologia, Instituto do Cora??o, Faculdade de Medicina da Universidade de S?o Paulo, S?o Paulo, SP, Brazil;4. Divis?o de Cirurgia, Instituto do Cora??o, Faculdade de Medicina da Universidade de S?o Paulo, S?o Paulo, SP, Brazil |
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| Abstract: | Trypanosoma cruzi, the agent of Chagas disease, is genetically classified into two major evolutionary lineages, T. cruzi I and T. cruzi II. In Southern American Cone countries it is T cruzi II which causes most cases of severe chronic Chagas disease. Contrary to this, we isolated T. cruzi I nested in endomyocardial biopsies of a chronic chagasic patient with end-stage heart failure. Our finding should alert clinicians to the possibility of severe Chagas disease in all regions where T. cruzi circulates, regardless of its lineage. |
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| Keywords: | Trypanosoma cruzi Chagas disease genetic typing cardiomyopathy endomyocardial biopsy T. cruzi lineages |
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