硫酸金刚烷胺注射液的一般药理学试验

目的　观察硫酸金刚烷胺注射液对实验动物的神经和心血管系统的影响。方法　对麻醉犬采用iv给药,给予硫酸金刚烷胺注射液 10、2 0、4 0mg·kg-1,观察对其颈动脉收缩压、舒张压、平均压,心电图各参数(P -R间期、QRS波群、Q -T间期、T波)及呼收频率和呼吸幅度等指标的影响;小鼠iv给药给予硫酸金刚烷胺注射液 15、30、6 0mg·kg-1,观察金刚烷胺对小鼠一般行为和机能协调功能等神经系统方面的影响。结果　在 4 0mg·kg-1的剂量时,犬的血压产生明显的降低,大约在 2h后有所恢复;对心率的作用也是在给药的 2 0min时开始减慢,同时在给药 10min时开始出现心律失常,出现室性早搏,停药后随即恢复,其Q -T段在 10～ 2 0min内有明显的延长,T波高度也有升高。但未见对犬的呼吸方面的明显影响。同时发现 6 0mg·kg-1的硫酸金刚烷胺注射液可显著提高小鼠的自发活动次数( P <0 0 5 ),对动物的机能协调能力也有轻微降低,但对阈下戊巴比妥钠催眠作用无明显协同作用。结论　高剂量的金刚烷胺可导致动物的血压下降和心律失常,但这种作用在停药后可恢复;高剂量的金刚烷胺可提高动物的行为活动,降低机能协调能力

Study on general Pharmacology of Amantadine sulfate injection

Objective To investigate the effects of Amantadine sulfate to nerve and cardiovascular systems.Methods Anaesthesia dogs were given Amantadine sulfate 10?20?40mg·kg -1 respectively by iv,then recorded the change of blood and cardiovascular parameters;Mice were given Amantadine sulfate 15?30?60mg·kg -1 respectively by iv,and observed the change of nerve system.Results The dog's blood showed reduce remarkablely and arrhythmia when given high dose of Amantadine sulfate at 20min;the self-motion is increase when mice was given high dose of Amantadine sulfate.Conlusion The high dose of Amantadine sulfate would influence the nerve and cardiovascular system of animals,and this action is reversible.