隔药饼灸对肝郁脾虚型功能性胃肠病大鼠胃排空、小肠推进功能影响等效性随机平行对照研究

目的]观察隔药饼灸对肝郁脾虚型功能性胃肠病大鼠胃排空、小肠推进功能影响。方法]使用随机平行对照方法,将60只SD大鼠编号按随机数字表法随机分为空白组(A)、模型组(B)、隔药饼灸组(C)、逍遥散组(D)和多潘立酮组(E)5组(12只/组)。A组正常饲养,不做任何干预;余4组均采用复合病因造模法(慢性束缚应激+过度疲劳+饮食失节+夹尾+摇晃)连续21d造模后,B组行捆绑束缚30min,并灌服生理盐水(各组灌胃容积均为1mL/100g体重);C组行隔药饼灸30min,灌服生理盐水;D组行捆绑束缚30min,灌服逍遥散;E组行捆绑束缚30min,灌服多潘立酮,连续干预14d。观测大鼠体重和食量、胃排空率、小肠推进率。结果]隔药饼灸组、逍遥散组与多潘立酮组体重和食量明显上升(P<0.05或P<0.01),三组间无明显差异(P>0.05);胃内残留率明显下降,小肠推进率明显升高(P<0.01);三组间无明显差异(P>0.05)。结论]隔药饼灸和逍遥散、多潘立酮具有等效性,可促进胃排空和小肠推进。

The Equivalence Random Parallel Control Study on the Influence of Herbal-cake-separatedmoxibustion on Gastric Emptying and Small Intestinal Propulsion in Functional Gastrointestinal Disorders' Rats with Syndrome of Liver Stagnation and Spleen Deficiency

Objective]To observe the influence of Herbal-cake-separated moxibustion on Gastric emptying and Small intestinal propulsion in Functional Gastrointestinal Disorders' Rats with syndrome of liver stagnation and spleen deficiency.Methods]Using random parallel control method,60 SD rats were randomly divided into 5 groups according to the table of random number method: Blank group(A),Model group(B),Herbal-cake-separated moxibustion group(C),Xiao-yao-san group(D) and Domperidone group(E),12 rats per group.Group A were normal feeding with no treatment,the other four groups with composite cause made moding(chronic restraint stress + excessive fatigue + irregular food) made model Continuously for 21 days and were intervened for 14 days.Then Group B was bounded for 30min and drenched normal saline at the same time,the lavage volume was 1mL/100g weight(the same below);Group C was applied Herbal-cake-separated moxibustion for 30min to the rats and drenched normal saline,Group D was bounded for 30min and drenched Xiaoyaosan,Group E was bounded for 30min and drenched Domperidone,the change of the rats weight and food intake、the gastric residual and small intestinal propulsion rate were observed after treatment.Results]The gastric residual rate in Herbal-cake-separated-moxibustion group,Xiaoyaosan group and Domperidone group is obviously lower than that of the model group,while the small intestinal propulsion rate is significantly higher than the model group,the differences are highly statistical significance(P<0.05 or P<0.01),but there is no difference in the three groups(P>0.05).Conclusion]The same as Xiaoyaosan and Domperidone,Herbal cake-separated-moxibustion can promote the gastric emptying and small intestinal propulsion,this may be one of the mechanism of its action.