| 隔药饼灸对功能性胃肠病肝郁脾虚模型大鼠MTL、GAS、VIP的影响 |
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| 引用本文： | 刘未艾,何亚敏,刘密,李金香,常小荣,章海凤.隔药饼灸对功能性胃肠病肝郁脾虚模型大鼠MTL、GAS、VIP的影响[J].实用中医内科杂志,2013(1):83-85,90. |
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| 作者姓名： | 刘未艾 何亚敏 刘密 李金香 常小荣 章海凤 |
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| 作者单位： | 湖南中医药大学第二附属医院针灸-脑病科;湖南中医药大学针灸推拿学院;湖南中医药大学第一附属医院针灸科 |
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| 基金项目： | 国家重点基础研究973计划项目(2009CB522904);国家自然科学基金(81173326);湖南省高校创新平台开放基金项目(12K087) |
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| 摘 要： | 目的]观察隔药饼灸对功能性胃肠病(Functional Gastrointestinal Disorders,FGIDs)肝郁脾虚模型大鼠胃肠激素的影响,探讨隔药饼灸治疗FGIDs的可能作用机制。方法]将60只SD大鼠随机分为空白组、模型组、隔药饼灸组、逍遥散组和多潘立酮组5组,每组12只,除空白组外其余4组采用复合病因造模法(慢性束缚应激+过度疲劳+饮食失节)造模,连续21d;再按被试因素施加方法每天进行隔药饼灸和逍遥散、多潘立酮灌胃14d。实验结束后取血清用ELISA法检测胃动素(Motilin,MTL)、胃泌素(Gastrin,GAS)和血管活性相关肠肽(Vasoactive Intestinal Peptide,VIP)的水平。结果]隔药饼灸组、逍遥散组与多潘立酮组大鼠MTL、GAS含量明显高于模型组,VIP含量明显低于模型组,差异均有高度统计学意义(P<0.05或P<0.01),但三组间比较差异无统计学意义(P>0.05)。结论]隔药饼灸组能和逍遥散组、多潘立酮组一样通过升高血清中MTL和GAS水平,降低VIP的水平从而达到促进胃肠运动的作用,这可能是其作用机制之一。
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| 关 键 词： | 功能性胃肠病 隔药饼灸 胃动素 胃泌素 血管活性相关肠肽 |
The Influence of Herbal-cake-separated-moxibustion on Motilin,Gastrin and Vasoactive Intestinal Peptide in Functional Gastrointestinal Disorders' Rats with Syndrome of Liver Stagnation and Spleen Deficiency |
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| Authors: | LIU Weiai HE Yamin LIU Mi LI Jinxiang CHANG Xiaorong ZHANG Haifeng |
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| Institution: | 1.The Acupuncture-Encephalopathy Department of the Second Affiliated Hospital to Hunan University of Traditional Chinese Medicine(TCM),Changsha 410005,China;2.2010 Postgraduate Student of the College of Acu-Moxibustion and Massage,Hunan University of TCM,Changsha 410007,China; 3.The College of Acu-Moxibustion and Massage,Hunan University of TCM,Changsha 410007,China; 4.The Acupuncture Department of the First Affiliated Hospital to Hunan University of TCM, Changsha 410007,China;5.2011 Doctor Graduate Student of the College of Acu-Moxibustion and Massage,Hunan University of TCM,Changsha 410007,China |
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| Abstract: | Objective]To observe the influence of Herbal-cake-separated-moxibustion on Gastrointestinal Hormone(MTL、GAS、VIP) in Functional Gastrointestinal Disorders' Rats with syndrome of liver stagnation and spleen deficiency to explore the possible mechanism of Herbal-cake-separated-moxibustion in treating Functional Gastrointestinal Disorders.Methods]60 SD rats were randomly divided into5 groups: Blank group,Model group,Herbal-cake-separated-moxibustion group,Xiaoyaosan group and Domperidone group,12 rats per group.In addition to the black group,the other four groups with composite cause made moding(chronic restraint stress + excessive fatigue + irregular food) made model,Continuous 21 days;Then according to the test factors applied method,practise Herbal cake separated moxibustion for 14 days,meanwhile the rats in the Xiaoyaosan group and Domperidone group were intragastric administration respectively for 14 days.After the experiment take the serum with ELISA method to detect Motilin 、Gastrin and Vasoactive Intestinal Peptide level.Results]The blood serum of MTL,GAS content in Herbal-cake-separated-moxibustion group,Xiaoyaosan group and Domperidone group are obviously higher than that of the model group,while the content of VIP is significantly lower than the model group,the differences are highly statistical significance(P<0.05 or P<0.01),but there is no difference in the three groups(P>0.05).Conclusion]Herbal-cake-separated-moxibustion can increase the blood serum of MTL and GAS level,reduce the VIP level so as to promote gastrointestinal movement effect the same as Xiaoyaosan and Domperidone,this may be one of the mechanism of its action. |
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| Keywords: | Functional Gastrointestinal Disorders Herbal-cake-separated-moxibustion Motilin Gastrin Vasoactive Intestinal Peptide |
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