复方虫草精华对心脏缺血/再灌注损伤的保护作用

目的：观察复方虫草精华（Lungfit)对大鼠离体心脏缺血／再灌注损伤是否存在保护作用。方法：Lungfit分小、大两个剂量（160、325mg/kg.d^-1)给大鼠连续灌胃给药10天后，取心脏，用Langendorff装置逆行恒压灌流，左心室内置乳胶水囊和换能器相连，分别测定缺血前后各组心脏的心功能参数值。结果：缺血前，Lungfit灌胃大鼠离体心脏的各项心功能参数值与对照组相比无显著差异（P＞0．05）；缺血30min后的再灌注期间，Lungfit灌饲的大鼠心脏的心率、冠脉流量及心肌舒缩功能的改善明显优于对照组（P＜0．05或P＜0．01）。结论：Lungfit对心肌缺血／再灌注损伤具有保护作用。

The Protective Effect of Lungfit on Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart

Objective To study the effect of Cordyceps sinensis compound (Lungfit) on myocardial ischemia/reperfusion injury in isolated rat heart.Methods Langendorff perfusion technique of rat heart was used to detect the myocardial function parameter at every 5 min intervals before ischemia and after reperfusion. Lungfit was administered by intragastric gavage at two different doses (160, 325 mg/kg.d -1 ) for 10 days consecutively.Results No statistical difference was observed between the Lungfit group and the control group before ischemia ( P >0 05). However, in the reperfusion period after 30 min global ischemia, the recovery of heart rate, coronary flow and systole/diastole function was markedly superior to that of control group.Conclusion Lungfit could produce a protective effect on myocardial ischemia/reperfusion injury.