血清成纤维细胞生长因子-21水平与2型糖尿病患者合并冠心病的相关性研究简 |
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引用本文: | 余健,何正飞,陈志云,孙凌刚.血清成纤维细胞生长因子-21水平与2型糖尿病患者合并冠心病的相关性研究简[J].全科医学临床与教育,2014(1):44-46. |
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作者姓名: | 余健 何正飞 陈志云 孙凌刚 |
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作者单位: | 富阳市人民医院心内科,浙江杭州311400 |
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摘 要: | 目的:评价血清成纤维细胞生长因子-21(FGF-21)的水平与2型糖尿病患者合并冠心病的相关性。方法将146名2型糖尿病患者分为合并冠心病组(66例)及未合并冠心病组(80例),采酶联免疫吸附法测定并比较两组血清FGF-21水平,采用Logistic回归分析评价FGF-21与合并冠心病的独立相关性。结果合并冠心病组高密度脂蛋白水平较未合并冠心病组明显降低,血清FGF-21水平较未合并冠心病组明显升高(t分别=3.89、-5.08,P均<0.05),多元Logistic回归分析结果显示高血清FGF-21水平与合并冠心病存在独立正相关关系(OR=1.65,95% CI为1.13~2.64)。结论高血清FGF-21水平是2型糖尿病患者合并冠心病的独立危险因素,FGF-21可能是评估2型糖尿病患者冠心病风险重要的生物学标记物。
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关 键 词: | 2型糖尿病 冠心病 成纤维细胞生长因子 |
Relationship between serum FGF-21 levels and type 2 diabetes combined with coronary artery disease |
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Institution: | YU Jian, HE Zhengfei, CHEN Zhiyun, et al. Department of Cardiology, Fuyang People's Hospital, Fuyang 311400, China |
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Abstract: | Objective To evaluate the relationship between fibroblast growth factor-21(FGF-21) levels and type 2 dia-betes(T2DM)combined with coronary artery disease(CAD). Methods One hundred and forty-six T2DM patients were di-vided into two groups: patients with CAD and patients without CAD. Serum FGF-21 levels were detected by enzyme-linked immunosorbent assay(ELISA). The association between serum FGF-21 levels and T2DM combined CAD was inves-tigated by logistic analysis. Results The high density lipoprotein in patients with CAD was significantly lower than that in patients without CAD while serum FGF-21 levels was significantly higher than that in patients without CAD (t=3.89,-5.08, P〈0.05). Multivariate logistic regression demonstrated that serum FGF-21 levels was independently positive related with T2DM combined with CAD (OR=1.65, 95%CI 1.13~2.64). Conclusion Higher FGF-21 in serum was an independent risk factor for T2DM combined with CAD. FGF-21 might be a promising biomarker for predicting the risk of CAD in T2DM patients. |
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Keywords: | type 2 diabetes coronary artery disease fibroblast growth factor |
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