High-dose naloxone affects task performance in normal subjects |
| |
| Authors: | R M Cohen M R Cohen H Weingartner D Pickar D L Murphy |
| |
| Affiliation: | 1. Robert M. Cohen, M.D., Ph.D., and Dennis L. Murphy, M.D., are in the Clinical Neuropharmacology Branch, National Institute of Mental Health (NIMH), USA;2. Martin R. Cohen, M.D., and David Pickar, M.D., are in the Section on Clinical Studies, Neuroscience Branch, NIMH, USA;3. Herbert Weingartner, Ph.D., is in the Laboratory of Psychology and Psychopathology, NIMH, USA |
| |
| Abstract: | Increasing intravenous doses of naloxone (0.3 mg/kg, 1 mg/kg, and 2 mg/kg) were administered to normal subjects. Naloxone at 2 mg/kg, but not at lower doses, impaired aspects of memory as measured by a verbal learning task which assessed the direct free recall and recognition of presented versus non-presented words of a single category (effortful processing) and the monitoring of the frequency of such presentations (automatic processing). At the same time "working" memory was left unaffected. The results suggest a role for the opioid system in some memory processes in man. |
| |
| Keywords: | Naloxone memory frequency automatic processing |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
