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肺耐药相关蛋白与肿瘤多药耐药相关性的研究进展
引用本文:刘津,唐安洲. 肺耐药相关蛋白与肿瘤多药耐药相关性的研究进展[J]. 医学综述, 2009, 15(19): 2944-2948
作者姓名:刘津  唐安洲
作者单位:广西医科大学第一附属医院耳鼻咽喉头颈外科,南宁,530021
基金项目:广西科学研究与技术开发计划 
摘    要:
耐药相关蛋白(LRP)又叫主穹隆蛋白(MVP),是一种在人体内普遍表达的蛋白,构成了细胞内已知的最大蛋白质之一——穹隆体,并参与核孔复合物的组成,对细胞核质物质转运起重要作用。随着对其的深入研究,发现LRP在细胞的生理代谢、自身保护、抗凋亡、抗感染、肿瘤的恶变以及多药耐药(MDR)的形成等过程中起着重要作用,同时其表达程度与肿瘤治疗效果以及预后也有一定的相关性。

关 键 词:肺耐药相关蛋白  穹隆  多药耐药  肿瘤

Advances of the Correlation between the LRP and MDR of Tumor
LIU Jin,TANG An-zhou. Advances of the Correlation between the LRP and MDR of Tumor[J]. Medical Recapitulate, 2009, 15(19): 2944-2948
Authors:LIU Jin  TANG An-zhou
Affiliation:LIU Jin, TANG An-zhou. ( Department of Otolaryngology-Head & Neck Surgery,the First Affiliated Hospital, Guangxi Medical University,Nanning 530021 ,China)
Abstract:
Lung resistance-related protein (LRP), also named as major vault protein (MVP) , is widely expressed in human tissue. It constructs one of the largest protein in cell which is called Vault. It is a main component of nuclear pore complex and plays an important role in nucleo-cytoplasmic transport. It is shown that LRP plays an important role in the metabolism, conservation, anti-apoptosis, anti-infection, as well as in the development of multidurg resistance and canceration of tumors. At the same time, researches show that the expression of LRP is correlated with the curative effect and prognosis of tumor.
Keywords:Lung resistance-related protein  Vault  Multidrug resistance  Tumor
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