西格列汀与沙格列汀治疗2型糖尿病的疗效对比研究

目的:比较西格列汀与沙格列汀治疗2型糖尿病的疗效。方法:将50例门诊初次确诊为2型糖尿病的患者随机分为西格列汀组和沙格列汀组各25例,分别用西格列汀或沙格列汀治疗12周,观察患者BMI、FPG、2 hPG、HbA1c等指标变化及低血糖发生情况。结果:治疗后两组FPG、2 hPG、HbA1c较治疗前均有明显下降,有统计学意义(P<0.01),BMI较治疗前均有轻度下降,但无统计学意义(P>0.05);两组间BMI、HbA1c、FPG、2 hPG、低血糖发生率等指标相比较无统计学意义(P>0.05)。结论:西格列汀及沙格列汀均能有效地控制2型糖尿病患者的血糖,轻度减轻体重,且低血糖发生率较低,但两者的疗效无明显差别。

The Comparative Study of the Efficacy of Sitagliptin and Saxagliptin Treating Type 2 Diabetes

Objective： To compare the efficacy of sitagliptin and saxagliptin treating type 2 diabetes. Methods： 50 Patients initially diagnosed as outpatients with type 2 diabetes were randomly assigned to sitagliptin group and saxagliptin group, each group had 25 patients, treated with sitagliptin or saxagliptin for 12 weeks respectively. Then observe the index changes of BMI, FPG, 2 hPG, HbA1 c and the incidences of hypoglycemia. Results： After treatment, FPG, 2 hPG, HbA1 c were significantly reduced compared with before in both groups（P0.01）, BMI had decreased slightly compared with before in both groups（P0.05）. Little changes were found between sitagliptin group and saxagliptin group on BMI, HbA1 c, FPG, 2 hPG and other indicators（P0.05）. Conclusion： Sitagliptin and saxagliptin can effectively decrease blood sugar in patients with type 2 diabetes, reduce weight lightly, and the incidence of hypoglycemia is very low.There is no difference on the efficacy between sitagliptin group and saxagliptin group.