环氧化酶-2与血管内皮生长因子在喉癌的表达及意义

目的探讨环氧化酶-2（COX-2）与血管内皮生长因子（VEGF）蛋白在喉鳞状细胞癌组织中表达的相关性。方法采用免疫组织化学SP法对76例喉癌组织与15例喉息肉进行COX-2与VEGF蛋白表达的染色，结合相关临床病理特征进行分析。结果COX-2与VEGF蛋白在喉癌组织的阳性表达率分别为51．32％和63．16％，均高于喉息肉（P〈0．01），二者均与喉癌浸润深度、组织分化程度密切相关，浸润越深、分化程度越差，表达越强（P〈0．05）；COX-2与淋巴结转移无明显相关（P〉0．05），VEGF则与淋巴结转移相关（P〈0．01），二者在喉癌组织的表达呈明显正相关（P〈0．05）。结论COX-2与VEGF在喉癌的发展中起重要作用，可能为喉癌的治疗提供新的靶点。

Expression and Significance of VEGF and COX-2 in Laryngeal Squamous Cell Carcinoma

Objective To investigate the significance of vascular endothelial growth factor(VEGF) and cyclooxygenase-2(COX-2) expression and correlation of them in laryngeal squamous cell carcinoma. Methods The expression of VEGF and COX-2 was determined with SP immunohistochemical analysis in 76 primary laryngeal carcinoma patients and 15 patients with polyp of larynx, and the associations of these proteins with pathological and clinical features were statistically analyzed. Results Positive rates of VEGF(63.16%) and COX-2(51.32%) in laryngeal carcinoma were significantly higher than those in polyp of larynx(P<0.01). The positive expression of VEGF and COX-2 in laryngeal carcinoma was correlated with the tumor differentiation and invasive depth(P<0.05). The positive expression of VEGF in laryngeal carcinoma was related to lamphnode metastasis (P<0.01). Positive correlations between the expression of VEGF and COX-2was found (P<0.05). Conclusion VEGF and COX-2 may play a key role in laryngeal carcinoma. All may have close relation in angiogenesis and may provide new targets for therapy of laryngeal carcinoma.