脐血来源间充质干细胞的分化潜能

背景：脐血源间充质干细胞是来源于发育早期中胚层的一类多能干细胞,因其具有多向分化潜能的特点而日益受到关注。目的：综述脐血来源间充质干细胞的诱导分化潜能。方法：应用计算机检索 Pubmed数据库中1999年1月至2012年12月关于脐血源间充质干细胞分化潜能的文章,在标题和摘要中以“umblical cord blood,mesenchymal stem cells,potential,differentiation”为检索词进行检索。最终选择关于脐血源间充质干细胞分化潜能的52篇文献进行综述。结果与结论：虽然很多实验已经证实人脐血间充质干细胞可以成功向多种细胞系分化,但对其了解程度尚浅。如果能掌握脐血间充质干细胞分化潜能的特点,那么很可能用它来修复许多骨缺损、心肌缺损等。目前研究正处于起步阶段,在分离纯化技术、分化方向的调控、体外扩增、免疫原性等方面尚有待进一步深入研究。

Differentiation potential of umbilical cord blood-derived mesenchymal stem cells

BACKGROUND:Umbilical cord blood-derived mesenchymal stem cells are multipotential stem cells in the mesoderm in early development stage, and have been paid great attention due to its properties of multi-directional differentiation. OBJECTIVE:To summarize the potential of induced differentiation of umbilical cord blood-derived mesenchymal stem cells.METHODS:We retrieved PubMed Database for articles concerning the differentiation potential of umbilical cord blood-derived mesenchymal stem cells published from January 1999 to December 2012. In titles and abstracts, the key words were “umblical cord blood, mesenchymal stem cells, potential, differentiation”. Totally, 52 articles addressing the differentiation potential of umbilical cord blood-derived mesenchymal stem cells were reviewed. RESULTS AND CONCLUSION:Numerous studies have confirmed that human umbilical cord blood-derived mesenchymal stem cells can successfully differentiate into multiple kinds of cell lines, but their understanding remains minor. If we can master the characteristics of the differentiation potential of umbilical cord blood-derived mesenchymal stem cells, it would be used to repair bone and myocardium detects. Present studies remain in a starting stage. Isolation and purification, regulation of differentiation direction, in vitro amplification and immunogenicity require further investigations.