干细胞移植与神经修复

背景：随着生命科学发展,利用干细胞来源的组织工程技术,有可能使受损的神经组织恢复再生能力。目的：针对较为重要的几种干细胞在神经系统修复中的临床应用做一综述,以期阐明各自适用范围和临床效度,为临床医师按需选择提供参考。方法：应用计算机检索PubMed 数据库中1998至2011年期间的关于干细胞移植在神经修复方面研究的文章,检索词为“Stem cells, Transplantation, Nerve repair”,限定语种为“English”。同时,检索万方数据库中2006至2011年期间的相关文章,检索词为“干细胞,移植,神经修复”,限定语种为中文。结果与结论：初次检索得到288篇文章,选择与移植干细胞的来源、分化、特征及其在神经修复方面相关的文章,包括基础研究和临床研究,观察对象无论为人或动物,均进行审校。根据纳入标准,在排除重复和个案报道类文章之后,重点选择32篇文章进行综述。说明干细胞移植为神经系统疾病的治疗提供了一条新途径,使传统认为的不可修复、不可再生的神经组织的结构修复和功能重建成为可能。干细胞移植是一个全新的领域,还有许多问题亟待解决。

Stem cell transplantation for nerve repair

BACKGROUND:With development of life science, tissue engineering technology involving stem cells likely enhances the regenerative capacity of injured nerve tissue.OBJECTIVE:To review the clinical application of several important stem cells in repair of nervous system injury and to clarify their application range and clinical validity, providing experimental evidence for clinical physicians.METHODS:A computer-based online retrieval of PubMed database was performed for the related articles regarding stem cell transplantation for nerve repair published during 1998-2011, with the key words “stem cells; transplantation; nerve repair” in English. Meanwhile, relevant articles published in Wanfang database during 2006-2011 were retrieved with key words “ stem cells; transplantation; nerve repair” in Chinese.RESULTS AND CONCLUSION:Through the initial retrieval, 284 basic research or clinical application papers were searched. These papers were analyzed in terms of source, differentiation, characteristics of transplanted stem cells as well as the effects of stem cell transplantation on nerve repair irrespective of humans or animals as subjects. After excluding papers with repetitive contents and case report papers, 28 papers were included in the final analysis. This suggests that stem cell transplantation provides a novel pathway to treatment of nervous system diseases and enables structure repair and functional reconstruction of nerve tissue that can be traditionally considered impossible. Stem cell transplantation is a brand-new research field and there are many problems to be solved.