| 低压稳恒直流电场促进兔梗死-缺血心肌血管新生的效应 |
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| 引用本文： | 何国祥,蒋清安,刘建平,苗莉,景涛.低压稳恒直流电场促进兔梗死-缺血心肌血管新生的效应[J].第三军医大学学报,2008,30(5):402-405. |
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| 作者姓名： | 何国祥 蒋清安 刘建平 苗莉 景涛 |
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| 作者单位： | 第三军医大学西南医院心血管内科,重庆市介入心脏病学研究所,重庆,400038 |
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| 摘 要： | 目的 探讨低压稳恒直流电场对兔梗死-缺血心肌毛细血管新生的效应.方法 将健康中国家兔40只分为心肌梗死(myocardial infarction,MI)组、平面电场2.0 V组、平面电场3.0 V组、透壁电场2.0 V组和透壁电场3.0 V组.4周后对梗死部位心肌组织进CD31免疫组织化学染色检测毛细血管密度.结果 透壁电场缩小梗死面积优于平面电场;透壁电场3.0 V可显著促进毛细血管新生和形成,尤以非梗死区明显.结论 适宜的低压稳恒直流电场具有促进兔MI/缺血模型心肌毛细血管新生的作用.
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| 关 键 词： | 电场 稳恒直流 冠状动脉 心肌梗死 血管新生 |
| 文章编号： | 1000-5404（2008）05-0402-04 |
| 收稿时间： | 2007-11-30 |
| 修稿时间： | 2008-01-04 |
Efficacy of weak steady direct current electrical fields in chronic myocardial infarction rabbits |
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| HE Guo-xiang,JIANG Qing-an,LIU Jian-ping,MIAO Li,JING Tao.Efficacy of weak steady direct current electrical fields in chronic myocardial infarction rabbits[J].Acta Academiae Medicinae Militaris Tertiae,2008,30(5):402-405. |
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| Authors: | HE Guo-xiang JIANG Qing-an LIU Jian-ping MIAO Li JING Tao |
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| Institution: | Department of Cardiology;Southwest Hospital;Third Military Medical University;Chongqing;400038;China |
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| Abstract: | Objective To investigate whether there is therapeutic angiogenic responses in ischemic myocardium of rabbit injured and chronic infracted heart under the weak steady direct current electrical fields (DCEFs) of 2.0 and 3.0 V/cm. Methods Forty Chinese rabbits established as myocardial infarction model without endotracheal intubation were randomly divided into 5 groups, i.e., myocardial infarction (MI) group, plane electrical fields of 2.0 V (PEF2V) group, the plane electrical fields of 3.0 V (PEF3V) group, tr... |
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| Keywords: | direct current electrotherapy coronary artery myocardial infarction therapeutic angiogenesis cardiac function |
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