Hypoglycemia Induced by Hydroxychloroquine Sulfate in a Patient Treated for Connective Tissue Disease Without Diabetes Mellitus |
| |
| Affiliation: | 1. Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China;2. Center for Drug Evaluation, National Medical Product Agency, Beijing, China;3. Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission, Shanghai, China;4. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China;5. Phase I Unit, Huashan Hospital, Fudan University, Shanghai, China;6. MicuRx Pharmaceuticals, Inc, Shanghai, China;1. Centre for Research on Health and Social Care Management, SDA Bocconi School of Management, Bocconi University, Milan, Italy;2. Oncology Unit, Policlinico di Milano, Milan, Italy;1. Astellas Pharma Inc, Tokyo, Japan;2. Astellas Pharma Inc, Ibaraki, Japan;3. Yanagibashi-Clinical Trial Center, Yanagibashi Hospital, Tokyo, Japan;1. Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland;2. Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland;3. Office of the Scientific Director, National Eye Institute, National Institutes of Health, Bethesda, Maryland;4. Section for Translational Research in Retinal and Macular Degeneration, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland |
| |
| Abstract: | PurposeSeveral case reports have highlighted symptomatic hypoglycemia as a serious but uncommon adverse effect of hydroxychloroquine (HCQ) in nondiabetic subjects.MethodsThis study describes a nondiabetic patient who experienced serious hypoglycemia related to HCQ.FindingsIn the course of treatment, the patient experienced multiple episodes of hypoglycemia at night and in the early morning. The hypoglycemia was usually accompanied by nausea, fatigue, and dizziness. The lowest value of blood glucose in the fingertip was 2.6 mmol/L.ImplicationsThis rare case will prompt clinicians to pay attention to unexplained hypoglycemia when using HCQ in nondiabetic patients. |
| |
| Keywords: | Connective tissue disease Gastrointestinal bleeding Hydroxychloroquine Hypoglycemia |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
