HBV感染与肝癌关系的Meta分析

目的:探讨我国人群HBV感染与肝癌的关联程度,为预防决策提供依据。方法:采用Meta分析法,对根据纳入标准和排除标准筛选出的24篇关于HBV感染与原发性肝癌关系的病例对照研究资料进行定量综合分析,比较固定效应模型和随机效应模型合并OR值的差异,比较剔除质量较差文献前后结论的差异,以评价Meta分析结果的稳定性。发表偏移的识别主要有漏斗图分析、线性回归法和失安全系数。结果:异质性检验χ2=29.59,P=0.16,采用固定效应模型进行Meta分析,合并OR=11.81,95%CI为10.33~13.50。结论:HBV感染与肝癌呈高度相关,我国居民应加强乙肝疫苗的免疫接种。

Meta Analysis of the Relationship on HBV Infection and Hepatic Carcinoma

Objective: To explore the relationship between hepatitis B virus infection and hepatic carcinoma and provide a basis for the preventive measurements.Methods: Twenty-four case-control studies on the relationship between hepatitis B virus and hepatic carcinoma were included according to the inclusion and exclusion standards.The included studies were analyzed synthetically by Meta-analysis.To evaluate the stability of the result,the combined OR value of fixed effect model and random effect model,the results of removing the poor quality studies or not are be compared.The funnel plot,the line regression and the fail-safe number are used to recognize the publication bias.Results: The statistic is equal to 29.59 and the value is equal to 0.16 in the heterogeneity test,so the fixed effect model is used for Meta-analysis.The combined OR is equal to 11.81,and its 95% confidence interval is between 10.33 and 13.50.Conclusions: The relationship between HBV infection and hepatic carcinoma was highly,so vaccine for Hepatitis B should be strenghthened.