Concise two-step chemical synthesis of molnupiravir |
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| Authors: | Viní cius R. D. Pereira,Marco A. M. Bezerra,Mauro R. B. P. Gomez,Guilherme M. Martins,Adilson D. da Silva,Kleber T. de Oliveira,Rodrigo O. M. A. de Souza,Giovanni W. Amarante |
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| Affiliation: | Department of Chemistry, Federal University of Juiz de Fora, Campus Martelos, Juiz de Fora Minas Gerais 36036-900 Brazil.; Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro Rio de Janeiro 22041-909 Brazil ; Department of Chemistry, Federal University of São Carlos, Campus São Carlos, São Carlos, São Paulo 13565-905 Brazil |
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| Abstract: | ![]()
A concise synthesis of molnupiravir in a one-pot two-step approach starting from uridine is described. Formally, herein, two sets of one-pot two-reaction steps introducing simplicity for purifications and using chemically available reagents are presented. In this context, molnupiravir was obtained in up to 68% overall yield and multigram-scale. In addition, HPLC analysis showed the molnupiravir purity above 99%.Fast, effective and chromatography column-free chemical synthesis of molnupiravir. |
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