Prevalence of von Hippel-Lindau gene mutations in sporadic renal cell carcinoma: results from the Netherlands cohort study |
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| Authors: | Kjeld?P?van Houwelingen,Boukje?AC?van Dijk mailto:Boukje.vanDijk@epid.unimaas.nl" title=" Boukje.vanDijk@epid.unimaas.nl" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Christina?A?Hulsbergen-van de Kaa,Leo?J?Schouten,Hanneke?JM?Gorissen,Jack?A?Schalken,Piet?A?van den Brandt,Egbert?Oosterwijk |
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| Affiliation: | (1) Department of Urology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, the Netherlands;(2) Department of Epidemiology, NUTRIM, Maastricht University, P.O. Box 616, 6200 Maastricht, MD, the Netherlands;(3) Department of Pathology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, the Netherlands |
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| Abstract: | ![]()
Background Biallelic von Hippel-Lindau (VHL) gene defects, a rate-limiting event in the carcinogenesis, occur in approximately 75% of sporadic clear-cell Renal Cell Carcinoma (RCC). We studied the VHL mutation status in a large population-based case group. |
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