糖尿病微血管病变患者血栓前状态标志物的改变与抗心磷酯抗体变化的关系

目的：探讨糖尿病微血管病变（DMA）患者血栓前状态标志物的改变及与自身抗体产生的关系。方法：采用免疫比浊法测定血浆纤维蛋白原（Fbg），酶联免疫吸附法（ELISA法）测定血浆中外周血浆因子Ⅷ相关抗原（VWFAg）、D-二聚体（（D-D）和抗心磷酯抗体（ACA）在DMA组、糖尿病无微血管病变组和正常组中的含量。结果：DMA组血浆中血栓前状态标志物Fbg、VWFAg及D-D和自身抗体ACA的水平明显高于糖尿病无微血管病变组和正常组（P〈0．05或P〈0．001），ACA水平的增高与Fbg、VWFAg及D-D水平的增高呈正相关，且ACA在DMA组中的阳性率显著高于糖尿病无微血管病变组和正常组（P〈0．05）。结论：糖尿病患者存在着凝血和纤溶功能的改变，在DMA时Fbg、VWFA、D-D等血栓前状态标志物增高更明显，与血栓形成密切相关的自身抗体ACA在DMA时的阳性率明显增高，且与Fbg、VWFA、D-D的增高呈正相关。因此，检测DMA患者的Fbg、VWFA、D-D和ACA水平对预防和治疗血栓形成及预后判断具有一定的临床意义。

Study on the relationship between changes of markers in prothrombotic state and anti-cardiolipin antibody in patients with diabetic microangiopathy

Objective:To explore the relationship between changes of markers in prothrombotic state and autoantibodies in patients with diabetic microangiopathy(DMA).Methods:The plasma levels of fibrinogen(Fbg),VWFAg,D-dimer(D-D)and anti-cardiolipin antibody(ACA)were detected in the patients with DMA,the patients without DMA and the healthy controls.The Fbg was measured by immunoturbidimetry and the VWFAg,D-D and ACA were measured by enzyme-linked immunosorbent assay(ELISA).Result:The levels of Fbg,VWFAg,D-D and ACA in...