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| 三氯乙烯染毒小鼠Th17细胞与肝功能损害的关系 | |
| 引用本文： | 王德骏,苏尧,赵文紧,王晓玮,马倩,刘猛,王进,沈彤. 三氯乙烯染毒小鼠Th17细胞与肝功能损害的关系[J]. 安徽医科大学学报, 2011, 46(11): 1147-1150 |
| 作者姓名： | 王德骏 苏尧 赵文紧 王晓玮 马倩 刘猛 王进 沈彤 |
| 作者单位： | 1. 安徽医科大学公共卫生学院,合肥,230032 2. 安徽医科大学公共卫生学院,合肥,230032;安徽医科大学皮肤病研究所,合肥,230032 |
| 基金项目： | 安徽省教育厅自然科学重点科研项目，安徽省自然科学基金，教育部科学技术研究重点项目 |
| 摘 要： | 目的 检测三氯乙烯(TCE)染毒小鼠体内Th17细胞数量及其分泌的白介素17(IL-17)含量和肝功能的变化,探讨Th17细胞与TCE引起的肝功能损害的关系.方法 雌性BALB/c小鼠随机分为TCE(2.5、5 mg/ml)组、空白对照组和溶剂对照组.染毒2、4、8、12周,采集外周血用全自动生化仪测定肝功能,处死动物... |
| 关 键 词： | 三氯乙烯 Th17细胞 肝脏毒性 |
Relationships of Th17 cells with liver functions damage in trichloroethylene exposed mice |
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| Wang Dejun,Su Yao,Zhao Wenjin,et al. Relationships of Th17 cells with liver functions damage in trichloroethylene exposed mice[J]. Acta Universitis Medicinalis Anhui, 2011, 46(11): 1147-1150 | |
| Authors: | Wang Dejun Su Yao Zhao Wenjin et al |
| Affiliation: | Wang Dejun,Su Yao,Zhao Wenjin,et al(School of Public Health,Anhui Medical University,Hefei 230032) |
| Abstract: | Objective To investigate the relationships of Th17 cells with liver functions damage in trichloroethylene(TCE) exposed mice.Methods Female BALB/c mice were intaked TCE(2.5,5 mg/ml) by drinking water;water and DMSO were served as blank and vehicle controls.At 2,4,8,12 weeks,blood were collected and assayed liver functions;liver and spleen biopsies were taken;Th17 cells number in spleen were measured by flow cytometry;IL-17 contents in liver homogenates were evaluated by ELISA.Results Compared with the contro... |
| Keywords: | trichloroethylene Th17 cell hepatoxicity |
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