| DNA修复基因XRCC3多态性与结肠癌易感性的关系 |
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| 引用本文： | 张嘉炜,孟翔凌. DNA修复基因XRCC3多态性与结肠癌易感性的关系[J]. 安徽医科大学学报, 2011, 46(11): 1172-1175 |
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| 作者姓名： | 张嘉炜 孟翔凌 |
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| 作者单位： | 安徽医科大学第一附属医院普通外科,合肥,230022;安徽医科大学第一附属医院普通外科,合肥,230022 |
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| 摘 要： | 目的 研究DNA修复基因XRCC3多态性及其与结肠癌易感性的关系.方法 选择80例经病理证实的结肠癌患者为肿瘤组,80例同期经门诊肠镜检查无异常的健康体检者为对照组,采用限制性片段长度多态性-聚合酶链反应(RFLP-PCR)法检测XRCC3基因C18607T的多态性分布,比较不同基因型与结肠癌易感性的关系.结果 XRC...
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| 关 键 词： | 修复基因 多态性 遗传易感性 结肠癌 |
Polymorphisms of DNA repair gene XRCC3 and susceptibility of colon carcinoma |
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| Zhang Jiawei,Meng Xiangling. Polymorphisms of DNA repair gene XRCC3 and susceptibility of colon carcinoma[J]. Acta Universitis Medicinalis Anhui, 2011, 46(11): 1172-1175 |
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| Authors: | Zhang Jiawei Meng Xiangling |
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| Affiliation: | Zhang Jiawei,Meng Xiangling(Dept of General Surgery,The First Affiliated Hospital of Anhui Medical University,Hefei 230022) |
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| Abstract: | Objective To study the relationship between the polymorphisms of DNA repair gene XRCC3 and susceptibility of colon carcinoma.Methods Selected eighty colon carcinoma patients as tumor cases and eighty health people as control cases.The XRCC3 C18607T genotypes were detected by restriction fragment length polymorphism-polymerase chain reaction(RFLP-PCR),and explored the relationship between the different genotypes and the susceptibility of colon carcinoma.Results The frequency of the XRCC3 C18607T genotypes C/... |
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| Keywords: | DNA repair gene polymorphisms genetic susceptibility colon carcinoma |
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