Correlation between microRNA-21, microRNA-206 and estrogen receptor,progesterone receptor,human epidermal growth factor receptor 2 in breast cancer |
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| Affiliation: | 1. Department of General Surgery, Chongqing Renji Hospital, University of Chinese Academy of Science, Chongqing 400062, China;2. Department of General Surgery, Hainan General Hospital, Hainan Medical University, Haikou 570311, Hainan, China;3. Department of General Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;1. Department of Neurology, Neurovascular Area, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain;2. Research Unit, University Hospital of Salamanca and Institute of Health Sciences of Castilla and Leon, Salamanca, Spain;3. Cellular and Molecular Neurobiology Research Group and Grup de Recerça en Neurociencies del IGTP, Department of Neurosciences, Fundació Institut d''Investigació en Ciències de la Salut Germans Trias I Pujol-Universitat Autónoma de Barcelona, Badalona, Spain;4. Single Molecule Fluorescence Research Unit, Department of Physical Chemistry, Faculty of Science, University of Santiago de Compostela, Lugo, Spain;1. Reconstructive Hip and Knee Joint Surgery, Rizzoli Orthopaedic Institute, Bologna, Italy;2. Pediatric Orthopedic and Traumatology, Rizzoli Orthopaedic Institute, Bologna, Italy;3. Rheumatology Unit, Department of Medicine, University Hospital of Padova, Padova, Italy;4. Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopedic Research Institute, Bologna, Italy;5. Orthopaedic Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy;6. Hospital for Special Surgery and Weill Cornell Medical College, New York, NY, USA |
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| Abstract: | ![]()
BackgroundAlthough the function of microRNA-21 and microRNA-206 in breast cancer cells have been investigated in vitro, their association with estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are not reported.MethodsER, PR, HER2, and Ki-67 staining pattern were utilized to classify 75 breast cancer patients recruited. The malignancy was predicted with tumor nodes metastases (TNM) classification. RT-qPCR was performed to detect the relative expression of ER, PR, and HER2 in tumor samples and microRNA-21 and microRNA-206 in the serum. Spearman's correlation analysis was used to determine the association between different molecules. According to the staining pattern, the breast cancer patients were classified into five types.ResultsmicroRNA-21 was up-regulated in HER2 positive and Basal-like breast cancer types, while microRNA-206 was up-regulated in Luminal A and B types of breast cancer. microRNA-21 expression negatively correlated with the level of ER and PR but positively correlated with HER2 expression and tumor malignancy, while microRNA-206 showed the opposite trend. Neither microRNA-21 nor microRNA-206 showed any significant correlation with the age of the patients.ConclusionBoth microRNA-21 and microRNA-206 closely correlate with ER, PR, and HER2 expression, which can be considered as clinical biomarkers. |
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