E838等5种辐射防护药对放烧复合伤防治作用的实验观察

目的 比较研究E838、WR-2721茜草、盐酸胱胺和炔雌醇等5种辐射防护药对放射损伤和放烧复合伤的防治作用及其相互间的协同作用。方法 采用小鼠腹腔注射、灌胃的方法在致伤前/或和致伤后按常用量给药,观察30d存活率,死亡动物平均存活日和保护系数K的差异。结果 （1）致伤前预防给药,5种药物均明显提高了放射损伤和放烧复合伤的存活率,并延长了死亡动物的平均存活日,其中以E838和WR-2721效果最佳;（2）致伤后给药则仅E838和茜草显示了治疗效果;（3）联合用药实验显示所研究的5种配伍用药方式均有较好的防治效果。但以WR-2721 E838治效果最好。结论 E838和WR-2721与其它辐射防护药相比具有较理想的辐射防护作用,且E838还有一定的治疗作用。两者合理配伍可发挥协同治疗作用。

Experimental study on preventive and therapeutic effec ts of 5 radioprotectants on combined radiation-burn injured mice

Objective　To compare the irradiation-protective and inter-synergestic effects of E838,WR-2721, Rubia cordifolia, cystamin e hydrochloride and ethinyl estradiol on radiation and combined radiation-burn injury. Methods　Above-mentioned drugs were given to the mice i ntraperitoneally, or intragastrcally, then, the mortality and the average surviv al d for 30 d were observed before and after the administration of the drug s. Results　①When drugs were before injury , the survival rate and the average survival d of the radiation and combined radiation-burn injured mice were increased obviously with the best effect in E838 and WR-2721. ②When drugs were given after injury, E838 and R. cordifolia also kept the effect. ③Combined appling WR-2721（pre) and E838（post）displayed a significant syner gistic reaction. Conclusion　E838 and WR-2721 are more e ffective than the others in the prevention of radiation.