The relationship of plasminogen activators and oncogenes to tumour invasion |
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| Authors: | J S Gelister P B Boulos P J Gaffney M Mahmoud M R Lewin |
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| Affiliation: | Department of Surgery, Faculty of Clinical Sciences, University College London, Rayne Institute. |
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| Abstract: | ![]()
Accruing evidence suggests an association between increased activity of plasminogen activators and transformed cells, and urokinase activity with tumour aggressiveness. The PIP2 pathway seems to provide a link between oncogene-associated transformation, cellular proliferation, plasminogen-activator expression and tumour invasion and metastasis. |
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